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Assistant Professor of Biomedical Engineering and Anesthesiology
Chronic Pain and Fatigue Research Center

Scott F. Lempka, PhD is an Assistant Professor in the Departments of Biomedical Engineering and Anesthesiology and the Director of the Neuromodulation Laboratory. The Neuromodulation Lab implements engineering approaches, such as computational modeling, to study the mechanism of action of clinical neuromodulation therapies for chronic pain management and other neurological disorders. The fundamental goal of the research program is to innovate future neuromostimulation technologies that dramatically improve patients’ lives.

Select Publications

Select publications

Fisher LE, Lempka SF. Neurotechnology for Pain. Annu Rev Biomed Eng. 2023 Jun 8;25:387-412.

Liang L, Damiani A, Del Brocco M, Rogers ER, Jantz MK, Fisher LE, Gaunt RA, Capogrosso M, Lempka SF, Pirondini E. A systematic review of computational models for the design of spinal cord stimulation therapies: from neural circuits to patient-specific simulations. J Physiol. 2022 Nov 21:10.1113/JP282884. Online ahead of print.

Graham RD, Jhand AS, Lempka SF. Dorsal root ganglion stimulation produces differential effects on action potential propagation across a population of biophysically distinct C-neurons. Front Pain Res (Lausanne). 2022 Oct 26;3:1017344.

Lee H, Graham RD, Melikyan D, Smith B, Mirzakhalili ELempka SF, Duan B. Molecular Determinants of Mechanical Itch Sensitization in Chronic Itch. Front Mol Neurosci. 2022 Jun 16;15:937890.

North RB, Lempka SF, Guan Y, Air EL, Poree LR, Shipley J, Arle J, Rigoard P, Thomson S. Glossary of Neurostimulation Terminology: A Collaborative Neuromodulation Foundation, Institute of Neuromodulation, and International Neuromodulation Society Project. Neuromodulation. 2022 Oct;25(7):1050-1058.

Rogers ERZander HJLempka SF. Neural recruitment during conventional, burst, and 10-kHz spinal cord stimulation for pain. J Pain. 2022 Mar;23(3):434-449.

Jones MG, Rogers ER, Harris JP, Sullivan A, Ackermann DM, Russo M, Lempka SF, McMahon SB. Neuromodulation using ultra low frequency current waveform reversibly blocks axonal conduction and chronic pain. Sci Transl Med. 2021 Aug 25;13(608):eabg9890. 

Graham RDSankarasubramanian VLempka SF. Dorsal root ganglion stimulation for chronic pain: Hypothesized mechanisms of action. J Pain. 2022 Feb;23(2):196-211.

Zander HJ, Kowalski KE, DiMarco AF, Lempka SF. Model-based optimization of spinal cord stimulation for inspiratory muscle activation. Neuromodulation. 2022 Dec;25(8):1317-1329.

Sankarasubramanian V, Chiravuri S, Mirzakhalili EAnaya CJ, Scott JR, Brummett CM, Clauw DJ, Patil PG, Harte SE, Lempka SF. Quantitative sensory testing of spinal cord and dorsal root ganglion stimulation in chronic pain patients. Neuromodulation. 2021 Jun;24(4):672-684.

Mirzakhalili E, Barra B, Capogrosso M, Lempka SF. Biophysics of temporal interference stimulation. Cell Syst. 2020 Dec 16;11(6):557-572.e5.

Jones SE, Lempka SF, Gopalakrishnan R, Baker KB, Beall EB, Bhattacharyya P, Huang X, Lin J, Chen J, Lowe MJ, Malone DA, Machado AG. Functional magnetic resonance imaging correlates of ventral striatal deep brain stimulation for poststroke pain. Neuromodulation. 2021 Feb;24(2):259-264.

Graham RD, Bruns TM, Duan B, Lempka SF. The effect of clinically controllable factors on neural activation during dorsal root ganglion stimulation. Neuromodulation. 2021 Jun;24(4):655-671.

Lempka SF. Can patient-specific computer models help in pain clinics using spinal cord stimulation? Bioelectronics in Medicine. 2020;3:1-4.

Capogrosso M, Lempka SF. A computational outlook on neurostimulation. Bioelectron Med. 2020 May 25;6:10.

Zander HJGraham RDAnaya CJLempka SF. Anatomical and technical factors affecting the neural response to epidural spinal cord stimulation. J Neural Eng. 2020 Jun 12;17(3):036019.

Khadka N, Liu Xijie, Zander H, Swami J, Rogers ELempka SF, Bikson M. Realistic anatomically detailed open-source spinal cord stimulation (RADO-SCS) model. J Neural Eng. 2020 Apr 23;17(2):026033.

Sperry ZJ, Graham RD, Peck-Dimit N, Lempka SF, Bruns TM. Spatial models of cell distribution in human lumbar dorsal root ganglia. J Comp Neurol. 2020 Jul;528(10):1644-1659.

Lempka SFZander HJAnaya CJ, Wyant A, Ozinga JG, Machado AG. Patient-specific analysis of neural activation during spinal cord stimulation for pain. Neuromodulation. 2020 Jul;23(5):572-581.

Anaya CJZander HJGraham RDSankarasubramanian VLempka SF. Evoked potentials recorded from the spinal cord during neurostimulation for pain: A computational modeling study. Neuromodulation. 2020 Jan;23(1):64-73.

Graham RD, Bruns TM, Duan B, Lempka SF. Dorsal root ganglion stimulation for chronic pain modulates Aβ-fiber activity but not C-fiber activity: A computational modeling study. Clin Neurophysiol. 2019 Jun;130(6):941-951.

Lempka SF and Patil PG. Innovations in spinal cord stimulation for pain. Curr Opin Biomed Eng. 2018 Dec;8:51-60.

Sankarasubramanian V, Harte SE, Chiravuri S, Harris RE, Brummett CM, Patil PG, Clauw DJ, Lempka SF. Objective measures to characterize the physiological effects of spinal cord stimulation in neuropathic pain: a literature review. Neuromodulation. 2019 Feb;22(2):127-148. 

Lempka SF, Howell B, Gunalan K, Machado AG, McIntyre CC. Characterization of the stimulus waveforms generated by implantable pulse generators for deep brain stimulation. Clin Neurophysiol. 2018 Apr;129(4):731-742.

Lempka SF, Malone DA Jr, Hu B, Baker KB, Wyant A, Ozinga JG 4th, Plow EB, Pandya M, Kubu CS, Ford PJ, Machado AG. Randomized clinical trial of deep brain stimulation for poststroke pain. Ann Neurol. 2017 May;81(5):653-663.

Lempka SF, McIntyre CC, Kilgore KL, Machado A. Computational analysis of kilohertz frequency spinal cord stimulation for chronic pain management. Anesthesiology. 2015 Jun;122(6):1362-76.