Endowed Professor of Medicine, Rheumatology, and Aging Research,
UC Davis
Director for the Center for Musculoskeletal Health,
UC Davis
Director, UC Davis
Center for Healthy Aging
Director, 12 NIH Building Interdisciplinary Research Careers in Women’s Health (BIRCWH)
Nancy E. Lane, MD is an Endowed Professor of Medicine, Rheumatology, and Aging Research, Director for the Center for Musculoskeletal Health, Director of the K12 NIH Building Interdisciplinary Research Careers in Women’s Health (BIRCWH), and Principal Investigator of the NIH funded Program on Sex Differences in Musculoskeletal Diseases Across the Lifespan at the University of California at Davis School of Medicine where she has served for the past 8 years.
Dr. Lane is an internationally recognized scientist in the fields of both osteoporosis and osteoarthritis.
Her translational research team has been instrumental in defining the role of glucocorticoids in bone fragility including their effects on cell stress and vulnerable cell populations
including osteocytes. As a faculty member at the University of California at San Francisco, she pioneered a seminal clinical trial to demonstrate that daily injections of the hormone PTH
could reverse glucocorticoid induced osteoporosis. After transitioning to U.C. Davis, she a developed a novel compound to direct stem cells to the bone to grow new bone and treat osteoporosis. In addition she has uncovered novel genetic variations that predispose individuals to osteoarthritis and has studied novel treatments for osteoarthritis.
She organized and directs an NIH funded junior faculty grant writing workshop that has taught over 300 junior faculty in musculoskeletal medicine grant writing skills that has resulted in a 45% success rate in applicants receiving research grants (2006-present).
Dr. Lane was President of the Board of the United States Bone and Joint Decade (2006-2008), co-led the International Bone and Joint Decade Conference in Washington DC (2010), was elected and serves on the council of the American Society of Bone and Mineral Research (2010-2013), and the Orthopedic Research Society.
Sessions at Neurovations Events
2018 Napa Pain Conference
- Pathophysiology of Osteoarthritis
Awards
Dr. Lane has been recognized by the University, her medical residents, subspecialty fellows, and by her faculty peers as an outstanding mentor with the UC Davis Dean’s Award for Scientific
Mentoring (2008).
Her research accomplishments have been recognized by the UC Davis School of Medicine Dean’s Team Science Award (2012), the American College of Rheumatology for the Oscar
Gluck Memorial Lecture for outstanding work in Osteoporosis (2011), the Remodeling in Bone “RIB Award” by the International Society of Bone and Mineral Research (2012), her election as a
Master of the American College of Physicians (2012) and David Trentham Lectureship and Women in Medicine Lectureship at Harvard Medical School (2013).
She is also the recipient of the Bone and Joint Decade Outstanding Achievement Award for developing a mentoring program in grant writing (2009).
Select Publications
- Clegg, D. O., Reda, D. J., Harris, C. L., Klein, M. A., O’Dell, J. R., Hooper, M. M., … & Lane, N. E. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine, 354(8), 795-808.
- Lane, N. E. (1997). Pain management in osteoarthritis: the role of COX-2 inhibitors. The Journal of rheumatology. Supplement, 49, 20-24.
- Lane, N. E., Schnitzer, T. J., Birbara, C. A., Mokhtarani, M., Shelton, D. L., Smith, M. D., & Brown, M. T. (2010). Tanezumab for the treatment of pain from osteoarthritis of the knee. New England Journal of Medicine, 363(16), 1521-1531.
- Lane, N. E. (2007). Osteoarthritis of the hip. New England Journal of Medicine, 357(14), 1413-1421.
- Manek, N. J., & Lane, N. E. (2000). Osteoarthritis: current concepts in diagnosis and management. American family physician, 61(6), 1795-1804.
- Felson, D. T., Lawrence, R. C., Dieppe, P. A., Hirsch, R., Helmick, C. G., Jordan, J. M., … & Sowers, M. (2000). Osteoarthritis: new insights. Part 1: the disease and its risk factors. Annals of internal medicine, 133(8), 635-646.
- Felson, D. T., Gross, K. D., Nevitt, M. C., Yang, M., Lane, N. E., Torner, J. C., … & Hurley, M. V. (2009). The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis. Arthritis Care & Research, 61(8), 1070-1076.
- Kim, C., Nevitt, M. C., Niu, J., Clancy, M. M., Lane, N. E., Link, T. M., … & Guermazi, A. (2015). Association of hip pain with radiographic evidence of hip osteoarthritis: diagnostic test study. Bmj, 351, h5983.
- Link, T. M., Steinbach, L. S., Ghosh, S., Ries, M., Lu, Y., Lane, N., & Majumdar, S. (2003). Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology, 226(2), 373-381.