Baker Family Director of Stanford ChEM-H, Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences and Professor, Nobel Prize Winner in Chemistry 2022
Professor Carolyn Bertozzi’s research interests span the disciplines of chemistry and biology with an emphasis on studies of cell surface sugars important to human health and disease. Her research group profiles changes in cell surface glycosylation associated with cancer, inflammation and bacterial infection, and uses this information to develop new diagnostic and therapeutic approaches, most recently in the area of immuno-oncology.
Dr. Bertozzi completed her undergraduate degree in Chemistry at Harvard University and her Ph.D. at UC Berkeley, focusing on the chemical synthesis of oligosaccharide analogs. During postdoctoral work at UC San Francisco, she studied the activity of endothelial oligosaccharides in promoting cell adhesion at sites of inflammation. She joined the UC Berkeley faculty in 1996. A Howard Hughes Medical Institute Investigator since 2000, she came to Stanford University in June 2015, among the first faculty to join the interdisciplinary institute ChEM-H (Chemistry, Engineering & Medicine for Human Health). She is now the Baker Family Director of Stanford ChEM-H.
The Bertozzi Group develops chemical tools to study the glycobiology underlying diseases such as cancer, inflammation, tuberculosis and most recently COVID-19. She is the inventor of “bioorthogonal chemistry”, a class of chemical reactions compatible with living systems that enable molecular imaging and drug targeting. Her group also developed new therapeutic modalities for targeted degradation of extracellular biomolecules, such as antibody-enzyme conjugates and Lysosome Targeting Chimeras (LYTACs). As well, her group studies NGly1 deficiency, a rare genetic disease characterized by loss of the human N-glycanase.
Several of the technologies developed in the Bertozzi lab have been adapted for commercial use. Actively engaged with several biotechnology start-ups, Dr. Bertozzi cofounded Redwood Bioscience, Enable Biosciences, Palleon Pharmaceuticals, InterVenn Bio, OliLux Bio, Grace Science LLC and Lycia Therapeutics. She is also a member of the Board of Directors of Lilly.
Sessions at Neurovations Events
- Lindahl Lecture 2023
Awards
- Nobel Prize Winner in Chemistry 2022
- Macarthur Fellow
- Lemelson-MIT Prize
- Heinrich Wieland Prize
- ACS Award in Pure ChemistryChemistry of the Future Solvay Prize
Select Publications
374. *Shao, Z.; *Flynn, R. A.; *Crowe, J. L.; *Zhu, Y.; Liang, J.; Jiang, W.; Aryan, F.; Aoude, P.; Bertozzi, C. R.; Estes, V. M.; Lee, B. J.; Bhagat, G.; †Zha, S.; †Calo, E. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature, ASAP.
373. Marschallinger, J.; Iram, T.; Zardeneta, M.; Lee, S. E.; Lehallier, B.; Haney, M. S.; Pluvinage, J. V.; Mathur, V.; Hahn, O.; Morgens, D. W.; Kim, J.; Tevini, J.; Felder, T. K.; Wolinski, H.; Bertozzi, C. R.; Bassik, M. C.; Aigner, L.; Wyss-Coray, T. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat. Neurosci. 2020, 23(2),194-208.
372. Bule, P.; Chuzel, L.; Blagova, E.; Wu, L.; Gray, M. A.; Henrissat, B.; Rapp, E.; Bertozzi, C. R.; Taron, C. H.; Davies, G. J. Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action. Nat. Comm. 2019, 10(1),4816.
371. Tsui, C. K.; Barfield, R. M.; Fischer, C. R.; Morgens, D. W.; Li, A.; Smith, B. A. H.; Gray, M. A.; Bertozzi, C. R.; Rabuka, D.; Bassik, M. C. CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity. Nat. Chem. Biol. 2019, 15(10),949-958.
370. Lim, H. C.; Sher, J. W.; Rodriguez-Rivera, F. P.; Fumeaux, C.; Bertozzi, C. R.; Bernhardt, T. G. Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae. PLoS Genet. 2019, 15(8),e1008284.
369. *Ooi, Y. S.; *Majzoub, K.; *Flynn, R. A.; Mata, M. A.; Diep, J.; Li, J. K.; van Buuren, N.; Rumachik, N.; Johnson, A. G.; Puschnik, A. S.; Marceau, C. D.; Mlera, L.; Grabowski, J. M.; Kirkegaard, K.; Bloom, M. E.; Sarnow, P.; Bertozzi, C. R.; Carette, J. E. An RNA-centric dissection of host complexes controlling flavivirus infection. Nat. Microbiol. 2019, 4(12),2369-2382.
368. Choi, J.; Wagner, L. J. S.; Timmermans, S. B. P. E.; Malaker, S. A.; Schumann, B.; Gray, M. A.; Debets, M. F.; Takashima, M.; Gehring, J.; Bertozzi, C. R. Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs. J. Am. Chem. Soc. 2019, 141(34),13442-13453.
367. *Möckl, L.; *Pedram, K.; Roy, A. R.; Krishnan, V.; Gustavsson, A. K.; Dorigo, O.; †Bertozzi, C. R.; †Moerner, W. E. Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx. Dev. Cell 2019, 50(1),57-72.e6.
366. *Shurer, C. R.; *Kuo, J. C.; *Roberts, L. M.; Gandhi, J. G.; Colville, M. J.; Enoki, T. A.; Pan, H.; Su, J.; Noble, J. M.; Hollander, M. J.; O’Donnell, J. P.; Yin, R.; Pedram, K.; Moeckl, L.; Kourkoutis, L. F.; Moerner, W. E.; Bertozzi, C. R.; Feigenson, G. W.; Reesink, H. L.; Paszek, M. J. Physical Principles of Membrane Shape Regulation by the Glycocalyx. Cell 2019, 177(7),1757-1770.e21.
365. Waldman, A. J.; Bertozzi, C. R. A Sugar Cloak of Invisibility. Biochemistry 2019, 14;58(19), 2385-2386.
364. Pluvinage, J. V.; Haney, M. S.; Smith, B. A. H.; Sun, J.; Iram, T.; Bonanno, L.; Li, L.; Lee, D. P.; Morgens, D. W.; Yang, A. C.; Shuken, S. R.; Gate, D.; Scott, M.; Khatri, P.; Luo, J.; Bertozzi, C. R.; Bassik, M. C.; Wyss-Coray, T. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature 2019, 568(7751),187-192.
363. *Malaker, S. A.; *Pedram, K.; Ferracane, M. J.; Bensing, B. A.; Krishnan, V.; Pett, C.; Yu, J.; Woods, E.C.; Kramer, J.R.; Westerlind, U.; Dorigo, O.; Bertozzi, C.R. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. PNAS 2019, 116(15),7278-7287.
362. *Appel, M. J.; *Meier, K. K.; Lafrance-Vanasse, J.; Lim, H.; Tsai, C. L.; Hedman, B.; Hodgson, K. O.; †Tainer, J. A.; †Solomon, E. I.; †Bertozzi, C.R. Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation. PNAS 2019, 116(12), 5370-5375.
361. Zhou, X.; Rodriguez-Rivera, F. P.; Lim, H. C.; Bell, J. C.; Bernhardt, T. G.; Bertozzi, C. R.; Theriot, J. A. Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum. Nat. Chem. Biol. 2019, 15(3),221-231.
360. Baranov, M. V.; Bianchi, F.; Schirmacher, A.; van Aart, M. A. C.; Maassen, S.; Muntjewerff, E. M.; Dingjan, I.; Ter Beest, M.; Verdoes, M.; Keyser, S. G. L.; Bertozzi, C. R.; Diederichsen, U.; van den Bogaart, G. The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience 2018, 11, 160-167.
359. Spiciarich, D. R.; Oh, S. T.; Foley, A.; Hughes, S. B.; Mauro, M. J.; Abdel-Wahab, O.; Press, R. D.; Viner, R.; Thompson, S. L.; Chen, Q.; Azadi, P.; Bertozzi, C. R.; Maxson, J. E. A novel germline variant in CSF3R reduces N-glycosylation and exerts potent oncogenic effects in leukemia. Cancer Res. 2018, 15;78(24), 6762-6770.
358. Walton, E. M.; Cronan, M. R.; Cambier, C. J.; Rossi, A.; Marass, M.; Foglia, M. D.; Brewer, W. J.; Poss, K. D.; Stainier, D. Y. R.; Bertozzi, C. R.; Tobin, D. M. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Host Microbe 2018, 24(4), 514-525.
357. *Barnes, J. M.; *Kaushik, S.; Bainer, R. O.; Sa, J. K.; Woods, E. C.; Kai, F.; Przybyla, L.; Lee, M.; Lee, H. W.; Tung, J. C.; Maller, O.; Barrett, A. S.; Lu, K. V.; Lakins, J. N.; Hansen, K. C.; Obernier, K.; Alvarez-Buylla, A.; Bergers, G.; Phillips, J. J.; Nam, D. H.; Bertozzi, C. R.; Weaver, V. M. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat. Cell Biol. 2018, 20(10), 1203-1214.
356. Wan, S. J.; Sullivan, A. B.; Shieh, P.; Metruccio, M. M. E.; Evans, D. J.; Bertozzi, C. R.; Fleiszig, S. M. J. IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea. Front Microbiol. 2018, 29(9), 1117.
355. Yang, A. C.; du Bois, H.; Olsson, N.; Gate, D.; Lehallier, B.; Berdnik, D.; Brewer, K. D.; Bertozzi, C. R.; Elias, J. E.; Wyss-Coray, T. Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics. J. Am. Chem. Soc 2018, 140(23), 7046-7051.
354. Keyser, S. G. L.; Utz, A.; Bertozzi, C. R. Computation-guided rational design of a peptide motif that reacts with cyanobenzothiazoles via internal cysteine-lysine relay. J. Org. Chem. 2018, 20;83(14), 7467-7479.
353. Tomlin, F. M.; Gordon, C. G.; Han, Y.; Wu, T. S.; Sletten, E. M.; Bertozzi, C. R. Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct. Bioorganic and Med. Chem. 2018, 15;26(19), 5280-5290.
352. *Kamariza, M.; *Shieh, P.; Ealand, C. S.; Peters, J. S.; Chu, B.; Rodriguez-Rivera, F. P.; Babu Sait, M. R.; Treuren, W. V.; Martinson, N.; Kalscheuer, R.; Kana, B. D.; Bertozzi, C. R. Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe. Sci. Transl. Med. 2018, 10(430), eaam6310. [Download PDF]
351. Aebersold, R.; Agar, J. N.; Amster, I. J.; Baker, M. S.; Bertozzi, C. R.; et al. How many human proteoforms are there? Nat. Chem. Bio. 2018, 14(3), 206-214.
350. Rodriguez-Rivera, F. P.; Zhou, X.; Theriot, J. A.; Bertozzi, C. R. Acute modulation of mycobacterial cell envelope biogenesis by front-line TB drugs. Angew. Chem. Int. Ed. Engl. 2018, 57(19), 5267-5272.
349. *Zhou, M.; *Delaveris, C. S.; Kramer, J. R.; Kenkel, J. A.; Engleman, E. G.; Bertozzi, C. R. N-carboxyanhydride polymerization of glycopolypeptides that activate antigen presenting cells through Dectin-1 and -2. Angew Chem Int Ed Engl. 2018, 57(12), 3137-3142.
348. *Tsai, C. T.; *Robinson, P. V.; Cortez, F. J.; Elma, M. L. B.; Seftel, D.; Pourmandi, N.; †Pandori, M. W.; †Bertozzi, C. R. Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis. Proc Natl Acad Sci U.S.A. 2018, 115(6), 1250-1255.
347. Woo, C.M.; Lund, P.J.; Huang, A. C.; Davis, M. M.; Bertozzi, C. R.; Pitteri, S. Mapping and quantification of over 2,000 O-linked glycopeptides in activated human T cells with isotope-targeted glycoproteomics (IsoTaG). Mol Cell Proteomics. 2018, 17(4), 764-775.
346. Freeman, S. A.; Vega, A.; Riedl, M.; Collins, R. F.; Ostrowski, P. P.; Woods, E. C.; Bertozzi, C. R.; Tammi, M. I.; Lidke, D. S.; Johnson, P.; Mayor, S.; Jaqaman, K.; Grinstein, S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018, 172, 305-317.
345. Kamariza, M.; Shieh, P.; Bertozzi, C. R. Imaging Mycobacterial Trehalose Glycolipids. Methods Enzymol. 2018, 598, 355-369.
344. Woods, E. C.; Kai, F.; Barnes, J.M.; Pedram, K.; Pickup, M. W.; Hollander, M.J.; Weaver, V. M.; Bertozzi, C. R. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 2017, 6:e25752.
343. *Tsai, C. T.; *Mukai, K.; Robinson, P. V.; Gray, M. A.; Waschmann, M. B.; Lyu, S. C.; Tsai, M.; Chinthrajah, R. S.; Nadeau, K. C.; †Bertozzi, C. R.; †Galli, S. J. Isotype-Specific Agglutination-PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE. J. Allergy Clin. Immunol. 2018, 141(5), 1901-1904.e15.
342. *Tomlin, F. M.; *Gerling-Driessen, U. I. M.; Liu, Y-C; Flynn, R. A.; Vangala, J. R.; Lentz, C. S.; Clauder-Muenster, S.; Jakob, P.; Mueller, W. F.; Ordoñez-Rueda, D.; Paulsen, M.; Matsui, N.; Foley, D.; Rafalko, A.; Suzuki, T.; Bogyo, M.; Steinmetz, L. M.; Radhakrishnan, S. K.; Bertozzi, C. R. Inhibition of NGLY1 onactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity. ACS Central 2017, 3, 1143-1155.
342. Spiciarich, D. R.; Nolley, R.; Maund, S. L.; Purcell, S. C.; Herschel, J.; Iavarone, A. T.; Peehl, D. M.; Bertozzi, C. R. Bioorthogonal labeling of human prostate cancer tissue slice cultures for glycoproteomics. Angew. Chem. Int. Ed. Engl. 2017, 56, 8992-8997.
341. Hinderlich, S.; Tauber, R.; Bertozzi, C. R.; Hackenberger, C. P. R. Werner Reutter: A visionary pioneer in molecular glycobiology. Chembiochem. 2017, 18, 1141-1145.
340. Andres, L. M.; Blong, I. W.; Evans, A.C.; Rumachik, N. G.; Yamaguchi, T.; Pham, N. D.; Thompson, P.; Kohler, J. J.; Bertozzi, C. R. Chemical modulation of protein O-GlcNAcylation via OGT inhibition promotes human neural cell differentiation ACS Chem. Biol. 2017, 18, 2030-2039.
339. Woo, C. M.; Felix, A.; Byrd, W. E.; Zuegel, D. K.; Ishihara, M.; Azadi, P.; Iavarone, A. T.; Pitteri, S. J.; Bertozzi, C. R. Development of IsoTaG, a chemical glycoproteomics technique for profiling intact N- and O-glycopeptides from whole cell proteomes. J. Proteome Res. 2017, 16 1706–1718.
338. Jolly, A. L.; Agarwal, P.; Metruccio, M. M.; Spiciarich, D. R.; Evans, D. J.; Bertozzi, C. R.; Fleiszig, S. M. Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding. FASEB J. 2017, 31, 2393-2404.
337. Ganesan, L.; Shieh, P.; Bertozzi, C. R.; Levental, I.Click-chemistry based high throughput screening platform for modulators of Ras palmitoylation. Sci Rep. 2017, 7, 41147.
336. Rodriguez-Rivera, F. P.; Zhou, X,; Theriot, J. A. ; Bertozzi, C, R.Visualization of mycobacterial membrane dynamics in live cells. J. Am. Chem. Soc. 2017, 139, 3488-3495.
335. Schump, M. D.; Fox, D. M.; Bertozzi, C. R.; Riley, L. W. Subcellular partitioning and intra-macrophage selectivity of antimicrobial compounds against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2017, 61, e01639-16.
334. Woo, C. M.; Felix, A.; Zhang, L.; Elias, J. E.; Bertozzi, C. R. Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars. Anal. Bioanal. Chem. 2017, 409, 579-588.
333. Palaniappan, K. K.; Bertozzi, C. R. Chemical glycoproteomics. Chem. Rev. 2016, 116, 14277-14306.
332. Sogi, K. M.; Holsclaw, C. M.; Fragiadakis, G. K.; Nomura, D. K.; Leary, J. A.; Bertozzi, C. R. Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis. ACS Infect. Dis. 2016, 2, 800-806.
331. Zhu, X.; Shieh, P.; Su, M.; Bertozzi, C. R.; Zhang, W. A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool. Chem. Commun. (Camb). 2016, 52, 11239-11242.
330. *Xiao, H.; *Woods, E. C.; Vukojicic, P.; Bertozzi, C. R. Precision glycocalyx editing as a strategy for cancer immunotherapy. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 10304-10309.
329. *Bhat, R.; *Belardi, B.; Mori, H.; Kuo, P.; Tam, A.; Hines, W. C.; Le, Q. T.; †Bertozzi, C. R.; †Bissell, M. J. Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E4820-E4827.
328. *Robinson, P. V.; *Tsai, C. T.; de Groot, A. E.; McKechnie, J. L.; Bertozzi, C. R. Glyco-seek: Ultrasensitive detection of protein-specific glycosylation by proximity ligation polymerase chain reaction. J. Am. Chem. Soc. 2016, 138,, 10722-10725.
327. *Hudak, J. E.; *Belardi, B.; Appel, M. J.; Solania, A.; Robinson, P. V.; Bertozzi, C. R. Piperidine-based glycodendrons as protein N-glycan prosthetics. Bioorg. Med. Chem. 2016, S0968-0896, 30383-30292.
326. Ngo, J. T.; Adams, S. R.; Deerinck, T. J.; Boassa, D.; Rodriguez-Rivera, F.; Palida, S. F.; Bertozzi, C. R.; Ellisman, M. H.; Tsien, R. Y. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat. Chem. Bio. 2016, 12, 459–465.
325. Sheta, R.; Woo, C. M.; Roux-Dalvai, F.; Fournier, F.; Bourassa, S.; Droit, A.; Bertozzi, C. R.; Bachvarov, D. A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. J. Prot. 2016, 145, 91-102.
324. Lantos, A. B.; Carlevaro, G.; Araoz, B.; Ruiz Diaz, P.; Camara, Mde. L.; Buscaglia, C. A.; Bossi, M.; Yu, H.; Chen, X.; Bertozzi, C. R.; †Mucci, J.; †Campetella, O. Sialic acid glycobiology unveils Trypanosoma cruzi trypomastigote membrane physiology. PLoS Pathog. 2016, 12, e1005559.
323. Woo, C. M.; Bertozzi, C R. Isotope targeted glycoproteomics (IsoTaG) to characterize intact, metabolically labeled glycopeptides from complex proteomes. Curr. Protoc. Chem. Biol. 2016, 8, 59-82.
322. Tsai, C.; Robinson, P. V.; Spencer, C. A.; Bertozzi, C. R. Ultrasensitive antibody detection by agglutination-PCR (ADAP). ACS Cent. Sci. 2016, 2, 139-147.
321. Freeman, S. A.; Goyette, J.; Furuya, W.; Woods, E. C.; Bertozzi, C. R.; Bergmeier, W.; Hinz, B.; van der Merwe, P. A.; Das, R.; Grinstein, S. Integrins form an expanding diffusional barrier that coordinates phagocytosis. Cell 2016, 164, 128-140.
320. Woods, E. C.; Yee, N. A.; Shen, J.; Bertozzi, C. R. Glycocalyx engineering with a recycling glycopolymer that increases cell survival in vivo. Angew. Chem. Int. Ed. Engl. 2015, 54, 15782-15788.
319. Kim, J.; Bertozzi, C. R. A bioorthogonal reaction of N-oxide and boron reagents. Angew. Chem. Int. Ed. Engl. 2015, Available online.
318. Varki, A.; Cummings, R. D.; Aebi, M.; Packer, N. H.; Seeberger, P. H.; Esko, J. D.; Stanley, P.; Hart, G.; Darvill, A.; Kinoshita, T.; Prestegard, J. J.; Schnaar, R. L.; Freeze, H. H.; Marth, J. D.; Bertozzi, C. R.; Etzler, M. E.; Frank, M. Vliegenthart, J. F.; Lütteke, T.; Perez, S.; Bolton, E.; Rudd, P.; Paulson, J.; Kanehisa, M.; Toukach, P.; Aoki-Kinoshita, K. F.; Dell, A.; Narimatsu, H.; York, W.; Taniguchi, N.; Kornfeld, S. Symbol nomenclature for graphical representations of glycans. Glycobiology 2015, 25, 1323-1324.
317. Kramer, J. R.; Onoa, B.; Bustamante, C.; Bertozzi, C. R. Chemically tunable mucin chimeras assembled on living cells. Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 12574-12579.
316. Robinson, P. V.; de Almeida-Escobedo, G.; de Groot, A. E.; McKechnie, J. L.; Bertozzi, C. R. Live-cell labeling of specific protein glycoforms by proximity-enhanced bioorthogonal ligation. J. Am. Chem. Soc. 2015, 137, 10452-10455.
315. Belardi, B.; Bertozzi, C. R. Chemical lectinology: tools for probing the ligands and dynamics of mammalian lectins in vivo. Chem Biol. 2015, 15, 259-268.
314. *Agarwal, P.; *Beahm B. J.; Shieh, P.; Bertozzi, C. R. Systemic fluorescence imaging of zebrafish glycans with bioorthogonal chemistry. Angew. Chem. Int. Ed. Engl. 2015. 54, 11504-11510.
313. Tapia, H.; Young, L.; Fox, D.; Bertozzi, C. R.; Koshland, D. Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 2015, 16, 6122-6127.
312. Shieh, P.; Dien, V. T.; Beahm, B. J.; Castellano, J. M.; Wyss-Coray, T.; Bertozzi, C. R. CalFluors: A universal motif for fluorogenic azide probes across the visible spectrum. J. Am. Chem. Soc. 2015, 22, 7145-7151.
311. Woo, C. M.; Iavarone, A. T.; Spiciarich, D. R.; Palaniappan, K. K.; Bertozzi, C. R. Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis. Nat. Methods. 2015, 6, 561-567.
310. Siegrist, M. S.; Aditham, A.; Espaillat, A.; Cameron, T. A.; Whiteside, S.; Cava, F.; Portnoy, D. A.; Bertozzi, C. R. Host actin polymerization tunes the cell division cycle of an intracellular pathogen. Cell Rep. 2015, 4, 499-507.
309. Kuhn, J.; Götting, C.; Beahm. B. J.; Bertozzi, C. R.; Faust, I.; Kuzaj, P.; Knabbe. C.; Hendig, D. Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum. Biochem. Biophys. Res. Commun. 2015, 3, 469-74.
308. Siegrist, M. S.; Swarts, B. M.; Fox, D. M.; Lim, S. A.; Bertozzi, C. R. Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface. FEMS Microbiol. Rev. 2015, 39,184-202.
307. Appel, M. J.; Bertozzi, C. R. Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications. ACS Chem. Biol. 2015, 10, 72-84.
306. Agarwal, P.; Bertozzi, C. R. Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug. Chem. 2014. 16, 176-192.
305. Touchette, M. H.; Holsclaw, C. M.; Previti, M. L.; Solomon, V. C.; Leary, J. A.; Bertozzi, C. R.; Seeliger, J. C. The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J Bacteriol. 2014.1m 201-10.
304. Shieh, P.; Bertozzi, C. R. Design strategies for bioorthogonal smart probes. Org. Biomol. Chem. 2014, 12, 9307-9320.
303. Meniche, X.; Otten, R.; Siegrist, M. S.; Baer, C. E.; Murphy, K. C.; Bertozzi, C. R.; Sassetti, C. M. Subpolar addition of new cell wall is directed by DivIVA in mycobacteria. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, E3243–E3251.
302. Paszek, M. J.; DuFort, C. C.; Rossier, O.; Bainer, R.; Mouw, J. K.; Godula, K.; Hudak, J. E.; Lakins, J. N.; Wijekoon, A. C.; Cassereau, L.; Rubashkin, M. G.; Magbanua, M. J.; Thorn, K. S.; Davidson, M. W.; Rugo, H. S.; Park, J. W.; Hammer, D. A.; Giannone, G.; Bertozzi, C. R.; Weaver, V. M. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature 2014, 511, 319-325.
301. Smith, E. L.; Bertozzi, C. R.; Beatty, K. E. An Expanded Set of Fluorogenic Sulfatase Activity Probes. Chembiochem. 2014, 15, 1101-1105.
300. Shieh, P.; Siegrist, M. S.; Cullen, A. J.; Bertozzi, C. R. Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 5456-5461.
299. Beahm, B. J.; Bertozzi, C. R. “Imaging Cell-Surface Glycans in Animals with Bioorthogonal Chemistry.” Glycoscience: Biology and Medicine. Ed. Endo, T.; Seeberger, P. H.; Hart, G. W.; Wong, C-H.; Taniguchi, T. Japan: Springer, 2014.1-11.
298. Smith, E. L.; Giddens, J. P.; Iavarone, A. T.; Godula, K.; Wang, L. X.; Bertozzi, C. R. Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags. Bioconjug. Chem. 2014, 25,788-795.
297. Sletten, E. M.; de Almeida, G.; Bertozzi, C. R. A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes. Org. Lett. 2014, 16, 1634-1637.
296. Beahm, B. J.; Dehnert, K. W.; Derr, N. L.; Kuhn, J.; Eberhart, J. K.; Spillmann, D,; Amacher, S. L.; Bertozzi, C. R. A Visualizable Chain-Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish. Angew. Chem. Int. Ed. Engl. 2014, 53, 3347-3352.
295. Siegrist, M. S.; Bertozzi, C. R. Mycobacterial lipid logic. Cell Host Microbe. 2014, 15, 1-2.
294. *Hudak, J. E.; *Canham, S. M.; Bertozzi, C. R. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nature Chem. Biol. 2014, 10, 69-75.
293. Hatzios, S. K.; Baer, C. E.; Rustad, T. R.; Siegrist, M. S.; Pang, J. M.; Ortega, C.; Alber, T.; Grundner, C.; Sherman, D. R.; Bertozzi, C. R. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, E5069-E5077.
292. Hudak, J. E.; Bertozzi, C. R. Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine. Chem. Biol. 2013, 21, 16-37.
291. Belardi, B.; de la Zerda, A.; Spiciarich, D. R.; Maund, S. L; Peehl, D. M.; Bertozzi, C. R. Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy. Angew. Chem. Int. Ed. Engl. 2013, 52, 14045-14049.
290. Bertozzi, C. R.; Wu, P. In vivo chemistry. Curr. Opin. Chem, Biol. 2013, 17, 717-718.
289. Palaniappan, K. K.; Hangauer, M. J.; Smith, T. J.; Smart, B. P.; Pitcher, A. A.; Cheng, E. H.; Bertozzi, C. R.; Boyce, M. A Chemical Glycoproteomics Platform Reveals O-GlcNAcylation of Mitochondrial Voltage-Dependent Anion Channel 2. Cell Rep. 2013, 5, 546-52.
288. Mauris, J.; Mantelli, F.; Woodward, A. M.; Cao, Z.; Bertozzi, C. R.; Panjwani, N.; Godula, K.; Argüeso, P. Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers. PLoS One 2013, 8, e72304.
287. Beatty, K. E.; Williams, M.; Carlson, B. L.; Swarts, B. M.; Warren, R. M.; van Helden, P. D.; Bertozzi, C. R. Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 12911-12916.
286. Sogi, K. M.; Gartner, Z. J.; Breidenbach, M. A.; Appel, M. J.; Schelle, M. W.; Bertozzi, C. R. Mycobacterium tuberculosis Rv3406 Is a Type II Alkyl Sulfatase Capable of Sulfate Scavenging. PLoS One 2013, 6, e65080.
285. Almeida, G. D.; Townsend, L. C.; Bertozzi, C. R. Synthesis and Reactivity of Dibenzoselenacycloheptynes. Org. Lett. 2013. Available ahead of print.
284. Shin, S. H.; Comolli, L, R.; Tscheliessnig, R.; Wang, C.; Nam, K. T.; Hexemer, A.; Siegerist, C. E.; De Yoreo, J. J.; Bertozzi, C. R. Self-Assembly of “S-Bilayers”, a Step Toward Expanding the Dimensionality of S-Layer Assemblies. A. C. S. Nano. 2013, 7, 4946-4953.
283. Comolli, L. R.; Siegerist, C. E.; Shin, S. H.; Bertozzi, C.; Regan, W.; Zettl, A.; De Yoreo, J. Conformational transitions at an S-layer growing boundary resolved by cryo-TEM. Angew. Chem. Int. Ed. Engl. 2013, 52, 4829-4832.
282. Van de Bittner, G. C.; Bertozzi, C. R.; Chang C. J. Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation. J. Am. Chem. Soc. 2013, 135, 1783-1795.
281. Siegrist, M. S.; Whiteside, S.; Jewett, J. C.; Aditham, A.; Cava, F.; Bertozzi, C. R. D-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen. ACS Chem. Biol. 2013. 8, 500-505.
280. Agarwal, P.; van der Weijden, J.; Sletten, E. M.; Rabuka, D.; Bertozzi, C. R. A Pictet-Spengler ligation for protein chemical modification. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 46-51.
279. *Shieh, P.; *Hangauer, M. J.; Bertozzi, C. R. Fluorogenic Azidofluoresceins for Biological Imaging. J. Am. Chem. Soc. 2012, 134, 17428-17431.
278. Swarts, B. M.; Holsclaw, C. M.; Jewett, J. C.; Alber, M.; Fox, D. M.; Siegrist, M. S.; Leary, J. A.; Kalscheuer, R.; Bertozzi, C. R. Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry. J. Am. Chem. Soc. 2012, 134, 16123-16126.
277. Godula, K.; Bertozzi, C. R. Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins. J. Am. Chem. Soc. 2012, 134, 15732-15742.
276. Henkin, A. H.; Cohen, A. S.; Dubikovskaya, E. A.; Park, H. M.; Nikitin, G. F.; Auzias, M. G.; Kazantzis, M.; Bertozzi, C. R.; Stahl, A. Real time non-invasive imaging of fatty acid uptake in vivo. A. C. S. Chem. Bio. 2012, 7 1884-1891.
275. *Shin, S. H.; *Chung S.; Sanii, B.; Comolli, L. R.; †Bertozzi, C. R.; †De Yoreo, J. J. Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 12968-12973.
274. Chang, P. V.; Bertozzi, C. R. Imaging beyond the proteome. Chem. Commun. (Camb). 2012. 48, 8864-8879.
273. Rabuka, D.; Rush, J. S.; deHart, G. W.; Wu, P.; Bertozzi, C. R.; Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat. Protoc. 2012, 5, 1052-1067.
272. Gordon, C. G.; Mackey, J. L.; Jewett, J. C.; Sletten, E. M.; †Houk, K. N.; †Bertozzi, C. R.; Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry. J. Am. Chem. Soc. 2012, 134, 9199-9208.
271. Belardi, B.; O’Donoghue, G. P.; Smith, A. W.; Groves, J. T.; Bertozzi, C. R. Investigating Cell Surface Galectin-Mediated Cross-linking on Glycoengineered Cells. J. Am. Chem. Soc. 2012, 134, 9549-9552.
270. Onoe, H.; Hsiao, S. C.; Douglas, E. S.; Gartner, Z. J.; Bertozzi, C. R.; Francis, M. B.; Mathies, R. A. Cellular Microfabrication: Observing Intercellular Interactions Using Lithographically-Defined DNA Capture Sequences. Langmuir 2012, 28, 8120-8126.
269. Yu, S. H.; Boyce, M.; Wands, A. M.; Bond, M. R.; Bertozzi, C. R.; Kohler, J. J. Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 4834-4839.
268. Hudak, J. E.; Barfield, R. M.; de Hart, G.W.; Grob, P.; Nogales, E.; Bertozzi, C.R.; Rabuka, D. Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag.. Angew Chem Int Ed Engl. 2012, 51, 4161-4165.
267. *Griffin, J. E.; *Pandey, A. K.; Gilmore, S. A.; Mizrahi, V.; McKinney, J. D.; Bertozzi, C. R.; Sassetti C.M. Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations. Chem Biol. 2012, 19, 218-227.
266. Gilmore, S. A.; Schelle, M. W.; Holsclaw, C. M.; Leigh, C. D.; Jain, M.; Cox, J. S.; Leary, J. A.; Bertozzi, C. R. Sulfolipid-1 Biosynthesis Restricts Mycobacterium tuberculosis Growth in Human Macrophages. ACS Chem Biol. 2012, 7, 863-870.
265. de Almeida, G.; Sletten, E. M.; Nakamura, H.; Palaniappan, K. K.; Bertozzi, C. R. Thiacycloalkynes for Copper-Free Click Chemistry. Angew Chem Int Ed Engl. 2012, 51, 2443-2447.
264. Seeliger, J. C.; Topp, S.; Sogi, K. M.; Previti, M. L.; Gallivan, J. P.; Bertozzi, C. R. A riboswitch-based inducible gene expression system for mycobacteria.. PLoS One. 2012, 7, e29266.
263. Dehnert, K. W.; Baskin, J. M.; Laughlin, S. T.; Beahm, B. J.; Naidu, N. N.; Amacher, S. L.; Bertozzi, C. R. Imaging the Sialome during Zebrafish Development with Copper-Free Click Chemistry. Chembiochem. 2012, 13, 353-357.
262. *Breidenbach, M. A.; *Palaniappan, K. K.; Pitcher, A. A.; Bertozzi, C. R. Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics. 2012, 11, M111.015339.
261. Yao, J. Z.; Uttamapinant, C.; Poloukhtine, A. A.; Baskin, J. M.; Codelli, J. A.; Sletten, E. M.; Bertozzi, C. R.; Popik, V. V.; Ting, A. Y. Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc. 2012, 134, 3720-3728.
260. *An, H. J.; *Gip, P.; Kim, J.; Wu, S.; Park, K. W.; McVaugh, C. T.; †Schaffer, D. V.; †Bertozzi, C. R.; †Lebirlla, C. B. Extensive Determination of Glycan Heterogeneity Reveals an Unusual Abundance of High-Mannose Glycans in Enriched Plasma Membranes of Human Embryonic Stem Cells Mol Cell Proteomics. 2012, 11, M111.010660.
259. Seeliger, J. C.; Holsclaw, C. M.; Schelle, M. W.; Botyanszki, Z.; Gilmore, S. A.; Tully, S. E.; Niederweis, M.; Cravatt, B. F.; Leary, J. A.; Bertozzi, C. R. Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2012, 287, 7990-8000.
258. Jewett, J. C.; Bertozzi, C. R. Synthesis of a Fluorogenic Cyclooctyne Activated by Cu-Free Click Chemistry. Org Lett. 2011, 13, 5937-5939.
257. Bertozzi, C. R. A decade of bioorthogonal chemistry. Acc. Chem. Res 2011, 44, 651-653.
256. Sletten, E. M.; Bertozzi, C. R. A bioorthogonal quadricyclane ligation. J. Am. Chem. Soc. 2011, 133, 17570-17573.
255. Hudak, J. E.; Yu H. H.; Bertozzi, C. R. Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag. J. Am. Chem. Soc. 2011, 40, 16127-35.
254. Sletten, E. M.; Bertozzi, C. R. From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions. Acc Chem Res. 2011, 44, 666-676.
253. Boyce, M.; Bertozzi, C. R. Bringing chemistry to life. Nat Methods. 2011, 8, 638-642.
252. Hatzios, S. K.; Bertozzi, C. R. The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis. PLoS Pathog. 2011, 7,e1002036.
251. Hatzios, S. K.; Schelle, M. W.; Newton, G. L.; Sogi, K. M.; Holsclaw, C. M.; Fahey, R. C.; Bertozzi, C. R. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011, 21, 4945-4950.
250. Hubbard, S. C.; Boyce M.; McVaugh, C. T.; Peehl, D. M.; Bertozzi, C. R. Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. Bioorg Med Chem Lett. 2011, 21, 4945-4950.
249. *Palaniappan, K. K.; *Pitcher, A. A.; *Smart, B. P.; Spiciarich, D. R.; Iavarone, A. T.; Bertozzi, C. R. Isotopic signature transfer and mass pattern prediction (IsoStamp): An enabling technique for chemically-directed proteomics. ACS Chem. Biol. 2011, 6, 829-836.
248. Dehnert, K. W.; Beahm, B. J.; Huynh, T. T.; Baskin, J. M.; Laughlin, S. T.; Wang, W.; Wu, P.; Amacher, S. L.; Bertozzi, C. R. Metabolic labeling of fucosylated glycans in developing zebrafish. ACS Chem. Biol. 2011, 6, 547-552.
247. Boyce, M.; Carrico, I. S.; Ganguli, A. S.; Yu, S.-H.; Hangauer, M. J.; Hubbard, S. C.; Kohler, J. J.; Bertozzi, C. R. Metabolic cross-talk allows labeling of O-linked ß-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 3141-3146.
246. Shui, W.; Petzold, C. J.; Redding, A.; Liu, J.; Pitcher, A.; Sheu, L.; Hsieh, T.; Keasling, J. D.; Bertozzi, C. R. Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation. J. Proteome Res. 2011, 10, 339-348.
245. Binda, O.; Boyce, M.; Rush, J. S.; Palaniappan, K. K.; Bertozzi, C. R.; Gozani, O. A chemical method for labeling lysine methyltransferase substrates. ChemBioChem 2011, 12, 330-334.
244. Jasti, R.; Bertozzi, C. R. Progress and challenges for the bottom-up synthesis of carbon nanotubes with discrete chirality. Chem. Phys. Lett. 2010, 494, 1-7.
243. Van de Bittner, G. C.; Dubikovskaya, E. A.; Bertozzi, C. R.; Chang, C. J. In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21316-21321.
242. Topp, S.; Reynoso, C. M.; Seeliger, J. C.; Goldlust, I. S.; Desai, S. K.; Murat, D.; Shen, A.; Puri, A. W.; Komeili, A.; Bertozzi, C. R.; Scott, J. R.; Gallivan, J. P. Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl. Environ. Microbiol. 2010, 76, 7881-7884.
241. Rush, J. S.; Beatty, K. E.; Bertozzi, C. R. Bioluminescent probes of sulfatase activity. ChemBioChem 2010, 15, 2096-2099.
240. Beatty, K. E.; Fisk, J. D.; Smart, B. P.; Lu, Y. Y.; Szychowski, J.; Hangauer, M. J.; Baskin, J. M.; Bertozzi, C. R.; Tirrell, D. A. Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. ChemBioChem 2010, 15, 2092-2095.
239. Chung, S.; Shin, S.-H.; Bertozzi, C. R.; De Yoreo, J. J. Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 16536-16541.
238. Sletten, E. M.; Nakamura, H.; Jewett, J. C.; Bertozzi, C. R. Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J. Am. Chem. Soc. 2010, 132, 11799-11805.
237. Godula, K.; Bertozzi, C. R. Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold. J. Am. Chem. Soc. 2010, 132, 9963-9965.
236. Chang, P. V.; Dube, D. H.; Sletten, E. M.; Bertozzi, C. R. A strategy for the selective imaging of glycans using caged metabolic precursors. J. Am. Chem. Soc. 2010, 132, 9516-9518.
235. Baskin, J. M.; Bertozzi, C. R. Copper-free click chemistry: bioorthogonal reagents for tagging azides. Aldrichimica Acta 2010, 43, 15-23.
234. Cohen, A. S.; Dubikovskaya, E. A.; Rush, J. S.; Bertozzi, C. R. Real-time bioluminescence imaging of glycans on living cells. J. Am. Chem. Soc. 2010, 132, 8563-8565.
233. *Baskin, J. M.; *Dehnert, K. W.; *Laughlin, S. T.; Amacher, S. L.; Bertozzi, C. R. Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 10360-10365.
232. Muia, R. P.; Yu, H.; Prescher, J. A.; Hellman, U.; Chen, X.; Bertozzi, C. R.; Campetella, O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology 2010, 20, 833-842.
231. Jewett, J. C.; Bertozzi, C. R. Cu-free click cycloaddition reactions in chemical biology. Chem. Soc. Rev. 2010, 39, 1272-1279.
230. Jewett, J. C.; Sletten, E. M.; Bertozzi, C. R. Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J. Am. Chem. Soc. 2010, 132, 3688-3690.
229. Breidenbach, M. A.; Gallagher, J. E. G.; King, D. S.; Smart, B. P.; Wu, P.; Bertozzi, C. R. Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 3988-3993.
228. *Chang, P. V.; *Prescher, J. A.; Sletten, E. M.; Baskin, J. M.; Miller, I. A.; Agard, N. J.; Lo, A.; Bertozzi, C. R. Copper-free click chemistry in living animals. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 1821-1826.
227. *Yap, M. C.; *Kostiuk, M. A.; Martin, D. D.; Perinpanayagam, M. A.; Hak, P. C.; Siddam, A.; Majjigapu, J. R.; Rajaiah, G.; Keller, B. O.; Prescher, J. A.; Wu, P.; Bertozzi, C. R.; Falck, J. R.; Berthiaume, L. G. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J. Lipid Res. 2010, 51, 1566-1580.
226. Laughlin, S. T.; Bertozzi, C. R. In Vivo Imaging of Caenorhabditis elegans Glycans. ACS Chem. Biol. 2009, 4, 1068-1072.
225. Varki, A.; Cummings, R. D.; Esko, J. D.; Freeze, H. H.; Stanley, P.; Marth, J. D.; Bertozzi, C. R.; Hart, G. W.; Etzler, M. E. Symbol nomenclature for glycan representation. Proteomics 2009, 9, 5398-5399.
224. Sletten, E. M.; Bertozzi, C. R. Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality. Angew. Chem., Int. Ed. 2009, 48, 6974-6998.
223. Godula, K.; Umbel, M. L.; Rabuka, D.; Botyanszki, Z.; Bertozzi, C. R.; Parthasarathy, R. Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers. J. Am. Chem. Soc. 2009, 131, 10263-10268.
222. Drake, P. M.; Stock, C. M.; Nathan, J. K.; Gip, P.; Golden, K. P.; Weinhold, B.; Gerardy-Schahn, R.; Bertozzi, C. R. Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 11995-12000.
221. Douglas, E. S.; Hsiao, S. C.; Onoe, H.; Bertozzi, C. R.; Francis, M. B.; Mathies, R. A. DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array. Lab Chip 2009, 9, 2010-2015.
220. Hsiao, S.C.; Shum, B.J.; Onoe, H.; Douglas, E.S.; Gartner, Z.J.; Mathies, R.A.; Bertozzi, C.R.; Francis, M.B. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir 2009, 25, 6985-6991.
219. Godula, K.; Rabuka, D.; Nam, K.T.; Bertozzi, C.R. Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-Like Glycopolymers for Microarray Applications. Angew. Chem., Int. Ed. 2009, 48, 4973-4976.
218. Song, J.; Xu, J.; Filion, T.; Saiz, E.; Tomsia, A. P.; Lian, J. B.; Stein, G. S.; Ayers, D. C.; Bertozzi, C. R. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J. Biomed. Mater. Res. 2009, 89, 1098-1107.
217. Perrine, C. L.; Ganguli, A.; Wu, P.; Bertozzi, C. R.; Fritz, T. A.; Raman, J.; Tabak, L. A.; Gerken, T. A. The glycopeptdie preferring polypeptide-GalNAc transferase-10 (ppGalNAc T10), involved in mucin type-O-glycosylation, has a unique GalNAc-O-Ser/Thr binding site in its catalytic domain not found in ppGalNAc T1 or T2. J. Biol. Chem. 2009, 284, 20387-20397.
216. Nessen, M. A.; Kramer, G.; Back, J.; Baskin, J. M.; Smeenk, L. E.; Van Maarseveen, J.; de Koning, L. J.; de Jong, L.; Bertozzi, C.; Hiemstra, H.; de Koster, C. G. Selective Enrichment of Azide-Containing Peptides from Complex Mixtures. J. Proteome Res. 2009, 8, 3702-3711.
215. Chang, P. V.; Chen, X.; Smyrniotis, C.; Xenakis, A.; Hu, T.; Bertozzi, C. R.; Wu, P. Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars. Angew. Chem., Int. Ed. 2009, 48, 4030-4033. [Download PDF]
214. Agard, N. J.; Bertozzi, C. R. Chemical Approaches to Perturb, Profile, and Perceive Glycans. Acc. Chem. Res. 2009, 42, 788-797.
213. Hur, G. H.; Meier, J. L.; Baskin, J.; Codelli, J. A.; Bertozzi, C. R.; Marahiel, M. A.; Burkart, M. D. Crosslinking Studies of Protein-Protein Interactions in Nonribosomal Peptide Biosynthesis. Chem. Biol. 2009, 16, 372-381.
212. Harland, C. W.; Botyanszki, Z.; Rabuka, D.; Bertozzi, C. R.; Parthasarathy, R. Synthetic Trehalose Glycolipids Confer Dessication Resistance to Supported Lipid Monolayers. Langmuir 2009, 25, 5193-5198.
211. Barb, A. W.; Leavy, T. M.; Robins, L. I.; Guan, Z.; Six, D. A.; Zhou, P.; Bertozzi, C. R.; Raetz, C. R. Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC. Biochemistry 2009, 48, 3068-3077.
210. Gartner, Z. J.; Bertozzi, C. R. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4606-4610.
209. Hatzios, S. K.; Schelle, M. W.; Holsclaw, C. M.; Behrens, C. R.; Botyanszki, Z.; Lin, F. L.; Carlson, B. L.; Kumar, P.; Leary, J. A.; Bertozzi, C. R. PapA3 is an acyltransferase required for Polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 2009, 284, 12745-12751.
208. Wu, P.; Shui, W.; Carlson, B. L.; Hu, N.; Rabuka, D.; Lee, J.; Bertozzi, C. R. Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 3000-3005.
207. Chen, X.; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A.; Bertozzi, C. R. Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells. J. Am. Chem. Soc. 2009, 131, 890-891.
206. Laughlin, S. T.; Bertozzi, C. R. Imaging the Glycome. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 12-17.
205. Wu, P.; Chen, X.; Hu, N.; Tam, U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. Biocompatible carbon nanotubes generated by functionalization with glycodendrimers. Angew. Chem., Int. Ed. 2008, 47, 5022-5025. [Download PDF]
204. Toriello, N. M.; Douglas, E. S.; Thaitrong, N.; Hsiao, S. C.; Francis, M. B.; Bertozzi, C. R.; Mathies, R. A. Integrated Microfluidic Bioprocessor for Single-Cell Gene Expression Analysis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 20173-20178.
203. Shui, W.; Gilmore, S. A.; Sheu, L.; Liu, J.; †Keasling, J. D.; †Bertozzi, C. R. Quantitative Proteomic Profiling of Host-Pathogen Interactions: The Macrophage Response to Mycobacterium tuberculosis Lipids. J. Prot. Res. 2008, 8, 282-289.
202. Jasti, R.; Bhattacharjee, J.; Neaton, J. B.; Bertozzi, C. R. Synthesis, Characterization, and Theory of [9]-, [12]-, and [18]Cycloparaphenylene: Carbon Nanohoop Structures. J. Am. Chem. Soc. 2008, 130, 17646-17647.
201. Drake, P. M.; Nathan, J. K.; Stock, C. M.; Chang, P. V.; Muench, M. O.; Nakata, D.; Reader, J. R.; Gip, P.; Golden, K. P.; Weinhold, B.; Gerardy-Schahn, R.; Troy, F. A. 2nd, Bertozzi, C. R. Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J. Immunol. 2008, 181, 6850-6858.
200. Shui, W.; Sheu, L.; Liu, J.; Smart, B.; Petzold, C. J.; Hsieh, T. Y.; Pitcher, A.; Keasling, J. D.; Bertozzi, C. R. Membrane proteomics of phagosomes suggests a connection to autophagy. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 16952-16957.
199. Holsclaw, C. M.; Sogi, K. M.; Gilmore, S. A.; Schelle, M. W.; Leavell, M. D.; Bertozzi, C. R.; Leary, J. A. Structural Characterization of a Novel Sulfated Menaquinone produced by stf3 from Mycobacterium tuberculosis. ACS Chem. Biol. 2008, 3, 619-624.
198. Hsiao, S. C.; Crow, A. K.; Lam, W. A.; Bertozzi, C. R.; Fletcher, D. A.; Francis, M. B. DNA-Coated AFM Cantilevers for the Investigation of Cell Adhesion and the Patterning of Live Cells. Angew. Chem., Int. Ed. 2008, 120, 8601-8605.
197. Czlapinski, J. L.; Schelle, M. W.; Miller, L. W.; Laughlin, S. T.; Kohler, J. J.; Cornish, V. W.; Bertozzi, C. R. Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization. J. Am. Chem. Soc. 2008, 130, 13186-13187.
196. Rush, J. S.; Bertozzi, C. R. New Aldehyde Tag Sequences Identified by Screening Formylglycine Generating Enzymes in Vitro and in Vivo. J. Am. Chem. Soc. 2008, 130, 12240-12241.
195. Codelli, J. A.; Baskin, J. M.; Agard, N. J.; Bertozzi, C. R. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry. J. Am. Chem. Soc. 2008, 130, 11486-11493.
194. Johnson, J. A.; Baskin, J. M.; Bertozzi, C. R.; Koberstein, J. T.; Turro, N. J. Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers. Chem. Commun. 2008, 3064-3066.
193. Paulick, M. G.; Bertozzi, C. R. The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins. Biochemistry 2008, 47, 6991-7000.
192. Sletten, E. M.; Bertozzi, C. R. A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry. Org. Lett. 2008, 10, 3097-3099.
191. Hatzios, S. K.; Iavarone, A. T.; Bertozzi, C. R. Rv2131c from Mycobacterium tuberculosis Is a CysQ 3′-Phosphoadenosine-5′-phosphatase. Biochemistry 2008, 47, 5823-5831.
190. *Laughlin, S. T.; *Baskin, J. M.; Amacher, S. L.; Bertozzi, C. R. In vivo imaging of membrane-associated glycans in developing zebrafish. Science 2008, 320, 664-667.
189. Rabuka, D.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes. J. Am. Chem. Soc. 2008, 130, 5947-5953.
188. Harland, C. W.; Rabuka, D.; Bertozzi, C. R.; Parthasarathy, R. The Mycobacterium tuberculosis Virulence Factor Trehalose Dimycolate Imparts Desiccation Resistance to Model Mycobacterial Membranes. Biophys. J. 2008, 94, 4718-4724.
187. Carlson, B. L.; Ballister, E. R.; Skordalakes, E.; King, D. S.; Breidenbach, M. A.; Gilmore, S. A.; Berger, J. M.; Bertozzi, C. R. Function and structure of a prokaryotic formylglycine-generating enzyme. J. Biol. Chem. 2008, 283, 20117-20125.
186. Hangauer, M. J.; Bertozzi, C. R. A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew. Chem., Int. Ed. 2008, 47, 2394-2397.
185. Leigh, C. D.; Bertozzi, C. R. Synthetic Studies toward Mycobacterium tuberculosis Sulfolipid-I. J. Org. Chem. 2008, 73, 1008-1017.
184. Martin, D. D.; Vilas, G. L.; Prescher, J. A.; Rajaiah, G.; Falck, J. R.; Bertozzi, C. R.; Berthiaume, L. G. Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J. 2008, 22, 797-806.
183. *Kostiuk, M. A.; *Corvi, M. M.; Keller, B. O.; Plummer, G.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R.; Rajaiah, G.; Falck, J. R.; Berthiaume, L. G. Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J. 2008, 22, 721-732.
182. Bertozzi, C. R.; Schelle, M. W. Sulfated Metabolites from Mycobacterium tuberculosis: Sulfolipid-1 and Beyond. In The Mycobacterial Cell Envelope, D. Mamadou & J.-M. Reyrat, Editors. ASM Press (Washington, DC), 2008.
181. Baskin, J. M.; Bertozzi, C. R. Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems. QSAR Comb. Sci. 2007, 26, 1211-1219.
180. Paulick, M. G.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 20332-20337.
179. Fernandez-Suarez, M.; Baruah, H.; Martinez-Hernandez, L.; Xie, K. T.; Baskin, J. M.; Bertozzi, C. R.; Ting, A. Y. Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat. Biotechnol. 2007, 25, 1483-1487.
178. Douglas, E. S.; Chandra, R. A.; Bertozzi, C. R.; Mathies, R. A.; Francis, M. B. Self-assembled cellular microarrays patterned using DNA barcodes. Lab Chip 2007, 7, 1442-1448.
177. Parthasarathy, R.; Rabuka, D.; Bertozzi, C. R.; Groves, J. T. Molecular orientation of membrane-anchored mucin glycoprotein mimics. J. Phys. Chem. B. 2007, 111, 12133-12135.
176. Baskin, J. M.; Prescher, J. A.; Laughlin, S. T.; Agard, N. J.; Chang, P. V.; Miller, I. A.; Lo, A.; Codelli, J. A.; Bertozzi, C. R. Copper-free click chemistry for dynamic in vivo imaging. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 16793-16797.
175. Paulick, M. G.; Wise, A. R.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. Synthetic analogues of glycosylphosphatidylinositol-anchored proteins and their behavior in supported lipid bilayers. J. Am. Chem. Soc. 2007, 129, 11543-11550.
174. Laughlin, S. T.; Bertozzi, C. R. Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation. Nat. Protoc. 2007, 2, 2930-2944.
173. Lin, F. L.; van Halbeek, H.; Bertozzi, C. R. Synthesis of Mono- and Dideoxygenated a,a-Trehalose Analogs. Carbohydr. Res. 2007, 342, 2014-2030.
172. Chang. P. V.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R. Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters. J. Am. Chem. Soc. 2007, 129, 8400-8401.
171. *Kumar, P.; *Schelle, M. W.; Jain, M.; Lin, F. L.; Petzold, C. J.; Leavell, M. D.; Leary, J. A.; Cox, J. S.; Bertozzi, C. R. PapA1 and PapA2 are Acyltransferases Essential for the Biosynthesis of the Mycobacterium tuberculosis Virulence Factor Sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 11221-11226.
170. Leavy, T. L.; Bertozzi, C. R. A High-Throughput Assay for O-GlcNAc Transferase Detects Primary Sequence Preferences in Peptide Substrates. Bioorg. Med. Chem. Lett. 2007, 7, 3851-3854.
169. Rabuka, D.; Parthasarathy, R.; Lee, G. S.; Chen, X.; Groves, J. T.; Bertozzi, C. R. Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers. J. Am. Chem. Soc. 2007, 129, 5462-5471.
168. *Carrico, I. S.; *Carlson, B. L.; Bertozzi, C. R. Introducing Genetically Encoded Aldehydes into Proteins. Nature Chem. Biol. 2007, 3, 321-322.
167. Jain, M; Petzold, C.J.; Schelle, M.W.; Leavell, M.D.; Mougous, J.D.; Bertozzi, C.R.; Leary, J.A.; Cox, J.S. Lipidomics Reveals Control of Mycobacterium tuberculosis Virulence Lipids via Metabolic Coupling. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 5133-5138.
166. Chen, X.; Kis, A.; Zettl, Z.; Bertozzi, C. R. A Cell Nanoinjector Based on Carbon Nanotubes. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 8218-8222.
165. Senaratne, R. H.; Mougous, J. D.; Reader, J. R.; Williams, S. J.; Zhang, T.; Bertozzi, C. R.; Riley, L. W. Vaccine Efficacy of Attenuated but Persistent Mycobacterium tuberculosis cysH Mutant. J. Med. Microbiol. 2007, 56, 454-458.
164. Gao, H.; Leary, J.; Carroll, K. S.; Bertozzi, C. R.; Chen, H. Noncovalent Complexes of APS Reductase from M. tuberculosis: Delineating a Mechanistic Model Using ESI-FTICR MS. J. Am. Soc. Mass Spectrom. 2007, 18, 167-178.
163. Laughlin, S. T.; Agard, N. J.; Baskin, J. M.; Carrico, I. S.; Chang, P. V.; Ganguli, A. S.; Hangauer, M. J.; Lo, A.; Prescher, J. A.; Bertozzi, C. R. Metabolic Labeling of Glycans with Azido Sugars for Visualization and Glycoproteomics. Methods Enzymol. 2006, 415, 230-250.
162. Czlapinski, J. L.; Bertozzi, C. R. Synthetic Glycobiology: Exploits in the Golgi Compartment. Curr. Opin. Chem. Biol. 2006, 10, 645-51.
161. Agard, N. J.; Baskin, J. M.; Prescher, J. A.; Lo, A.; Bertozzi, C. R. A Comparative Study of Bioorthogonal Reactions with Azides. ACS Chem. Biol. 2006, 1, 644-8.
160. *Kehoe, J. W.; *Velappan, N.; Walbolt, M.; Rasmussen, J.; King, D.; Lou, J.; Knopp, K.; Pavlik, P.; Marks, J.; †Bertozzi, C. R.; †Bradbury, A. R. M. Using Phage Display to Select Antibodies Recognizing Post-translational Modifications Independently of Sequence Context. Mol. Cell. Proteomics 2006, 5, 2350-63.
159. Chartron, J.; Carroll, K. S.; Shiau, C.; Gao, H.; Leary, J. A.; Bertozzi, C. R.; Stout, C. D. Substrate Recognition, Protein Dynamics, and Iron-Sulfur Cluster in Pseudomonas aeruginosa Adenosine 5’-Phosphosulfate Reductase. J. Mol. Biol. 2006 364, 152-69.
158. Rabuka, D.; Hubbard, S. C.; Laughlin, S. T.; Argade, S. P.; Bertozzi, C. R. A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation. J. Am. Chem. Soc. 2006, 128, 12078-9.
157. Schelle, M. W.; Bertozzi, C. R. Sulfate Metabolism in Mycobacteria. ChemBioChem 2006, 7, 1516-24.
156. Prescher, J. A.; Bertozzi, C. R. Chemical Technologies for Probing Glycans. Cell 2006, 126, 851-854.
155. Stowell, C. L.; Barvian, K. K.; Young, P. C.; Bigsby, R. M.; Verdugo, D. E.; Bertozzi, C. R.; Widlanski, T. S. A Role for Sulfation-Desulfation in the Uptake of Bisphenol A Into Breast Tumor Cells. Chem. Biol. 2006, 13, 891-897.
154. Link, A. J.; Vink, M. K.; Agard, N. J.; Prescher, J. A.; Bertozzi, C. R.; Tirrell, D. A. Discovery of Aminoacyl-tRNA Synthetase Activity Through Cell Surface Display of Noncanonical Amino Acids. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 10180-5.
153. Chen, X.; Tam, U. C.; Czlapinski, J. L.; Lee, G. S.; Rabuka, D.; Zettl, A.; Bertozzi, C. R. Interfacing Carbon Nanotubes with Living Cells. J. Am. Chem. Soc. 2006, 128, 6292-3.
152. *Dube, D. H.; *Prescher, J. A.; Quang, C. N.; Bertozzi, C. R. Probing Mucin-type O-linked Glycosylation in Living Animals. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4819-24.
151. Juan Perez-Vilar, Raean Mabolo, Cheryl T. McVaugh, Carolyn R. Bertozzi, and Richard C. Boucher. Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells. Roles of Protein Post-translational Modifications and Secretion. J. Biol. Chem. 2006, 281, 4844-55.
150. Senaratne, R. H.; DeSilva, D.; Williams, S. J.; Mougous, J. D.; Zhang, T.; Chan, S.; Sidders, B.; Chan, J.; Bertozzi, C. R.; W. Riley, L. W. 5’-Adenosinephosphosulphate Reductase (CysH) Protects Mycobacterium tuberculosis Against Free Radicals During Chronic Infection Phase in Mice. Mol. Microbiol. 2006, 59, 1744-53.
149. Mougous, J. D.; Senaratne, R. H.; Petzold, C. J.; Jain, M.; Lee, D. H.; Schelle, M. W.; Leavell, M. D.; Cox, J. S.; Leary, J. A.; Riley, L. W.; Bertozzi, C. R. A Sulfated Metabolite Produced by stf3 Negatively Regulates the Virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4258-63.
148. Rush, J. S.; Bertozzi, C. R. An a-formylglycine building block for Fmoc-based solid phase peptide synthesis. Org. Lett. 2006, 8, 131-134.
147. Mougous, J. D.; Lee, D. H.; Hubbard, S. C.; Schelle, M. W.; Vocadlo, D. J.; Berger, J. M.; Bertozzi, C. R. Molecular Basis for G protein Control of ATP Sulfurylase in Bacteria. Molecular Cell 2006, 21, 109-122.
146. Chandra, R. A.; Douglas, E. S.; Mathies, R. A.; Bertozzi, C. R.; Francis, M. B. Programmable Cell Adhesion Encoded by DNA Hybridization. Angew. Chem., Int. Ed. 2006, 45, 896-901.
145. *Carroll, K. S.; *Gao, H.; Chen, H.; Leary, J. A.; Bertozzi, C. R. Investigation of the Iron-Sulfur Cluster in Mycobacterium tuberculosis APS Reductase: Implications for Substrate Binding and Catalysis. Biochemistry 2005, 44, 14647-14657.
144. Tomsia, A. P.; Saiz, E.; Song, J.; Bertozzi, C. R. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005, 7, 999-1004.
143. Hang, H. C.; Bertozzi, C. R. The Chemistry and Biology of Mucin-Type O-Linked Glycosylation. Bioorg. Med. Chem. 2005, 13, 5021-5034.
142. Carroll, K. S.; Gao, H.; Chen, H.; Stout, C. D.; Leary, J. A.; Bertozzi, C. R. A Conserved Mechanism for Sulfonucleotide Reduction. PloS Biology 2005, 3 (8), e250.
141. Grogan, M. J.; Kaizuka, Y.; Conrad, R. M.; Groves, J. T.; Bertozzi, C. R. Synthesis of Lipidated Green Fluorescent Protein and its Incorporation in Supported Lipid Bilayers. J. Am. Chem. Soc., 2005, 127, 14383-14387.
140. Prescher, J. A.; Bertozzi, C. R. Chemistry in Living Systems. Nature Chem. Biol. 2005, 1, 13-21.
139. Dube, D. H.; Bertozzi, C. R. Glycans in Cancer and Inflammation – Potential for Therapeutics and Diagnostics. Nature Rev. Drug Disc. 2005, 4, 477-88.
138. Saad, O. M.; Ebel, H.; Uchimura, K.; Rosen, S. D.; Bertozzi, C. R.; Leary, J. A. Compositional Profiling of Heparin/Heparan Sulfate Using Mass Spectrometry: Assay for Specificity of a Novel Extracellular Human Endosulfatase. Glycobiology 2005, 15, 818-826.
137. Pi, N.; Hoang, M. B.; Gao, H.; Mougous, J. D.; Bertozzi, C. R.; Leary, J. A. Kinetic Measurements and Mechanism Determination of Stf0 Sulfotransferase Using Mass Spectrometry. Anal. Biochem. 2005, 341, 94-104.
136. Song, J.; Malathong, V.; Bertozzi, C. R. Mineralization of Synthetic Polymer Scaffolds: A Bottom-up Approach for the Development of Artificial Bone. J. Am. Chem. Soc. 2005, 127, 3366-3372.
135. Lin, F., Hoyt, H. M.; van Halbeek, H.; Bergman, R. G.; Bertozzi, C. R. Mechanistic Investigation of the Staudinger Ligation. J. Am. Chem. Soc. 2005, 127, 2686-2695.
134. Pratt, M. R.; Bertozzi, C. R. Synthetic Glycopeptides and Glycoproteins as Tools for Biology and as Therapeutic Agents. Chem. Soc. Rev. 2005, 34, 58-68.
133. Samuel, J.; Bertozzi, C. R. Chemical Tools for the Study of Polysialic Acid. Trends in Glycoscience 2004, 91, 305-318.
132. Vocadlo, D. J.; Bertozzi, C. R. A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates. Angew. Chem., Int. Ed. 2004, 43, 5338-5342.
131. Tian, E.; Ten Hagen, K. G.; Shum, L.; Hang, H. C.; Imbert, Y.; Young, W. W., Jr.; Bertozzi, C. R.; Tabak, L. A. An Inhibitor of O-Glycosylation Induces Apoptosis in NIH3T3 Cells and Developing Mouse Embryonic Mandibular Tissues. J. Biol. Chem. 2004, 279, 50382-50390.
130. Agard, N. J.; Prescher, J. A.; Bertozzi, C. R. A Strain-Promoted [3+2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems. J. Am. Chem. Soc. 2004, 126, 15046-15047.
129. Song, J.; Bertozzi, C. R. Functional Polymers for Bone Tissue Engineering Applications, In Handbook of Nanostructured Materials and Their Applications in Nanobiotechnology, H. S. Nalwa, Editor. American Scientific Publishers, 2005. Vol 1, pp 1-22.
128. Chen, X.; Lee, G. S.; Zettl, A.; Bertozzi, C. R. Biomimetic Engineering of Carbon Nanotubes By Using Cell Surface Mimics. Angew. Chem., Int. Ed. 2004, 43, 6112-6116.
127. Luchansky, S. J.; Argade, S.; Hayes, B. K.; Bertozzi, C. R. Metabolic Functionalization of Recombinant Glycoproteins. Biochemistry 2004, 43, 12358-12366.
126. *Prescher, J. A.; *Dube, D. H.; Bertozzi, C. R. Chemical Remodelling of Cell Surfaces in Living Animals. Nature 2004, 430, 873-877.
125. Luchansky, S. J.; Bertozzi, C. R. Azido Sialic Acids can Modulate Cell Surface Interactions. ChemBioChem 2004, 5, 1706-1709.
124. Kohler, J. J.; Czlapinski, J. L.; Laughlin, S. T.; Schelle, M. W.; de Graffenried, C. L.; Bertozzi, C. R. Directing Flux in Glycan Biosynthetic Pathways with a Small Molecule Switch. ChemBioChem 2004, 5, 1455-1458.
123. de Graffenried, C. L.; Laughlin, S. T.; Kohler, J. J.; Bertozzi, C. R. A Small-Molecule Switch for Golgi Sulfotransferases. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16715-16720.
122. de Graffenried, C. L.; Bertozzi, C. R. The Stem Region of the Sulfotransferase GlcNAc6ST-1 is a Determinant of Substrate Specificity. J. Biol. Chem. 2004, 279, 40035-40043.
121. Song, J.; Chen, J.; Klapperich, C. M.; Eng, V.; Bertozzi, C. R. Functional Glass Slides for In Vitro Evaluation of Interactions Between Osteosarcoma TE85 Cells and Mineral-Binding Ligands. J. Mat. Chem. 2004, 14, 2643-2648.
120. de Graffenried, C. L.; Bertozzi, C. R. The Roles of Enzyme Localisation and Complex Formation in Glycan Assembly within the Golgi Apparatus. Curr. Opin. Cell Biol. 2004, 16, 356-363.
119. Song, J.; Cisar, J. S.; Bertozzi, C. R. Functional Self-Assembling Bolaamphiphilic Polydiacetylenes as Colorimetric Sensor Scaffolds. J. Am. Chem. Soc. 2004, 126, 8459-8465.
118. Mougous, J. D.; Petzold, C. J.; Senaratne, R. H.; Lee, D. H.; Akey, D. L.; Lin, F. L.; Munchel, S. E.; Pratt, M. R.; Riley, L. W.; Leary, J. A.; Berger, J. M.; Bertozzi, C. R. Identification, Function and Structure of the Mycobacterial Sulfotransferase that Initiates Sulfolipid-1 Biosynthesis. Nature Struct. Mol. Biol. 2004, 11, 721-729.
117. Woodruff, P. J.; Carlson, B. L.; Siridechadilok, B.; Pratt, M. R.; Mougous, J. D.; Senaratne, R.; Riley, L. W.; Williams, S. J.; Bertozzi, C. R. Trehalose is Required for Growth of Mycobacterium smegmatis. J. Biol. Chem. 2004, 279, 28835-28843.
116. Pratt, M. R.; Bertozzi, C. R. Syntheses of 6-Sulfo Sialyl Lewis X Glycans Corresponding to the L-Selectin Ligand “Sulfoadhesin”. Org. Lett. 2004, 6, 345-2348.
115. Pratt, M. R.; Hang, H. C.; Ten Hagen, K. G.; Rarick, J.; Gerken, T. A.; Tabak, L. A.; Bertozzi, C. R. Deconvoluting the Functions of Polypeptide N-a-Acetylgalactosaminyltransferase (ppGalNAcT) Family Members by Glycopeptide Substrate Profiling. Chem. Biol. 2004, 11, 1009-1016.
114. Klapperich, C. M.; Bertozzi, C. R. Global Gene Expression Patterns of Cells Attached to a Tissue Engineering Scaffold. Biomaterials 2004, 25, 5631-5641.
113. Macmillan, D.; Bertozzi, C. R. Modular Assembly of Glycoproteins: Toward the Synthesis of GlyCAM-1 by Using Expressed Protein Ligation. Angew. Chem., Int. Ed. 2004, 43, 1355-1359.
112. Hang, H. C.; Yu, C.; Ten Hagen, K. G.; Tian, E.; Winans, K. A.; Tabak, L. A.; Bertozzi, C. R. Small Molecule Inhibitors of Mucin-type O-Linked Glycosylation from a Uridine-based Library. Chem. Biol. 2004, 11, 337-345.
111. Grossman, H. L.; Myers, W. R.; Vreeland, V. J.; Bruehl, R.; Alper, M. D.; Bertozzi, C. R.; Clarke, J. Detection of Bacteria in Suspension by Using a Superconducting Quantum Interference Device. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 129-134.
110. *Luchansky, S. J.; *Goon, S.; Bertozzi, C. R. Expanding the Diversity of Unnatural Cell Surface Sialic Acids. ChemBioChem 2004, 5, 371-374.
109. Hang, H. C.; Yu, C.; Pratt, M. R.; Bertozzi, C. R. Probing Glycosyltransferase Activities with the Staudinger Ligation. J. Am. Chem. Soc. 2004, 126, 6-7.
108. Hang, H. C.; Yu, C.; Kato, D. L.; Bertozzi, C. R. A Metabolic Labeling Approach Towards Proteomic Analysis of Mucin-type O-Linked Glycosylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 14846-14851.
107. Kohler, J. J.; Bertozzi, C. R. Regulating Cell Surface Glycosylation by Small Molecule Control of Enzyme Localization. Chem. Biol. 2003, 10, 1303-1311.
106. Verdugo, D. E.; Pedersen, L. C.; Bertozzi, C. R. Small Molecule Inhibitors of the Sulfotransferases, in Carbohydrate-Based Drug Discovery, Wong, C.-H., Ed. Wiley-VCH, 2003. pp 781-797.
105. Dube, D. H.; Bertozzi, C. R. Metabolic Oligosaccharide Engineering as a Tool for Glycobiology. Curr. Opin. Chem. Biol. 2003, 7, 616-625.
104. Wojczyk, B. S.; Stwora-Wojczyk, M. M.; Hagen, F. K.; Striepen, B.; Hang, H. C.; Bertozzi, C. R.; Roos, D. S.; Spitalnik, S. L. cDNA Cloning and Expression of UDP-N-acetyl-D-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol. Biochem. Parasitol., 2003, 131, 93-107.
103. Pratt, M. R.; Leigh, C. D.; Bertozzi, C. R. Formation of 1,1-a,a-Glycosidic Bonds by Intramolecular Aglycone Delivery. A Convergent Synthesis of Trehalose. Org. Lett. 2003, 5, 3185-3188.
102. de Graffenried, C. L.; Bertozzi, C. R. Golgi Localization of Carbohydrate Sulfotransferases is a Determinant of L-Selectin Ligand Biosynthesis. J. Biol. Chem. 2003, 278, 40282-40295.
101. Song, J.; Saiz, E.; Bertozzi, C. R. Preparation of pHEMA-CP Composites with High Interfacial Adhesion via Template-Driven Mineralization. J. Eur. Ceramic Soc. 2003, 23, 2905-2919.
100. Vocadlo, D. J.; Hang, H. C.; Kim, E. J.; Hanover, J. A.; Bertozzi, C. R. A Chemical Approach for Identifying O-GlcNAc Modified Proteins in Cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 9116-9121.
99. Converse, S. E.; Mougous, J. M.; Leavell, M. D.; Leary, J. A.; Bertozzi, C. R.; Cox, J. S. MmpL8 is Required for Sulfolipid Biosynthesis and M. tuberculosis Virulence. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 6121-6126.
98. Pratt, M. R.; Bertozzi, C. R. Chemoselective Ligation Applied to the Synthesis of a Biantennary N-Linked Glycoform of CD52. J. Am. Chem. Soc. 2003, 125, 6149-6159.
97. Goon, S.; Schilling, B.; Tullius, M. V.; †Gibson, B. W.; †Bertozzi, C. R. Metabolic Incorporation of Unnatural Sialic Acids into Haemophilus ducreyi Lipooligosaccharides. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3089-3094.
96. Lemieux, G. A.; de Graffenried, C. L.; Bertozzi, C. R. A Fluorogenic Dye Activated by the Staudinger Ligation. J. Am. Chem. Soc. 2003, 128, 4708-4709.
95. Luchansky, S. J.; Yarema, K. J.; Bertozzi, C. R. GlcNAc 2-Epimerase Can Serve a Catabolic Role in Sialic Acid Metabolism. J. Biol. Chem. 2003, 278, 8035-8042.
94. Song, J.; Saiz, E.; Bertozzi, C. R. A New Approach to Mineralization of Biocompatible Hydrogel Scaffolds: An Efficient Process Toward 3-Dimensional Bonelike Composites. J. Am. Chem. Soc. 2003, 125, 1236-1243.
93. Marcaurelle, L. A.; Pratt, M. R.; Bertozzi, C. R. Synthesis of Thioether-Linked analogs of the 2,3-Sialyl-TF and MECA-79 Antigens: Mucin-Type Glycopeptides Associated with Cancer and Inflammation. ChemBioChem. 2003, No. 2-3, 224-228.
92. Luchansky, S. J.; Hang, H. C.; Saxon, E.; Grunwell, J. R.; Yu, C.; Dube, D. H.; Bertozzi, C. R. Constructing Azide-Labeled Cell Surfaces Using Polysaccharide Biosynthetic Pathways. Meth. Enzymol. 2003, 362, 249-272.
91. Scherman, M. S.; Winans, K. A.; Stern, R. J.; Jones, V.; Bertozzi, C. R.; McNeil, M. R. Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Development of a Microtiter Plate-Based Screen for UDP-galactopyranose Mutase and Identification of an Inhibitor from a Uridine-Based Library. Antimicrobial Agents and Chemotherapy 2003, 47, 378-382.
90. Armstrong, J. I.; Verdugo, D. E.; Bertozzi, C. R. Synthesis of a Bisubstrate Analog Targeting Estrogen Sulfotransferase. J. Org. Chem. 2003, 68, 170-173.
89. *Mougous, J. D.; *Leavell, M. D.; Senaratne, R. H.; Leigh, C. D.; Williams, S. J.; Riley, L. W.; †Leary, J. A.; †Bertozzi, C. R. Discovery of Sulfated Metabolites in Mycobacteria With a Genetic and Mass Spectrometric Approach. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 17037-17042.
88. Saxon, E.; Luchansky, S. J.; Hang, H. C.; Yu, C.; Lee, S. C.; Bertozzi, C. R. Investigating Cellular Metabolism of Synthetic Azidosugars Using the Staudinger Ligation. J. Am. Chem. Soc. 2002, 124, 14893-14902.
87. Grunwell, J. R.; Rath, V. L.; Rasmussen, J.; Cabrilo, Z.; Bertozzi, C. R. Characterization and Mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. Biochemistry 2002, 41, 15590-15600.
86. Grunwell, J. R.; Bertozzi, C. R. Carbohydrate Sulfotransferases of the GalNAc/Gal/GlcNAc6ST Family. Biochemistry 2002, 41, 13117-13126.
85. *Parak, W. J.; *Gerion, D.; Zanchet, D.; Woerz, A. S.; Pellegrino, R.; Micheel, C.; Williams, S. C.; Seitz, M.; Bruehl, R. E.; Bryant, Z.; Bustamante, C.; Bertozzi, C. R.; Alivisatos, A. P. Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots. Chem. Mater. 2002, 14, 2113-2119.
84. Pi, N.; Armstrong, J. I.; Bertozzi, C. R.; Leary, J. A. Kinetic Analysis of NodST Sulfotransferase Using an Electrospray Ionization Mass Spectrometry Assay. Biochemistry 2002, 41, 13283-13288.
83. Mougous, J. D.; Green, R. E.; Williams, S. J.; Brenner, S. E.; Bertozzi, C. R. Sulfotransferases and Sulfatases in Mycobacteria. Chem. Biol. 2002, 9, 767-776.
82. Williams, S. J.; Senaratne, R. H.; Mougous, J. D.; Riley, L. W.; Bertozzi, C. R. 5’-Adenosinephosphosulfate Lies at a Metabolic Branchpoint in Mycobacteria. J. Biol. Chem. 2002, 277, 32606-32615.
81. Verdugo, D. E.; Bertozzi, C. R. A 96-Well Dot-Blot Assay for Carbohydrate Sulfotransferases. Anal. Biochem. 2002, 307, 330-336.
80. Grogan, M. J.; Pratt, M. R.; Marcaurelle, L. A.; Bertozzi, C. R. Homogeneous Glycopeptides and Glycoproteins for Biological Investigation. Annu. Rev. Biochem. 2002, 71, 593-634.
79. Conrad, R. M.; Grogan, M. J.; Bertozzi, C. R. Stereoselective Synthesis of myo-Inositol via Ring-Closing Metathesis: A Building Block for Glycosylphosphatidylinositol (GPI) Anchor Synthesis. Org. Lett. 2002, 4, 1359-1361.
78. Charter, N; Mahal, L. K.; Koshland, D. E., Jr.; Bertozzi, C. R. Differential Effects of Unnatural Sialic Acids on the Polysialylation of NCAM and Neuronal Behavior. J. Biol. Chem. 2002, 277, 9255-9261.
77. Winans, K. A.; Bertozzi, C. R. An Inhibitor of the Human UDP-GlcNAc 4-Epimerase Identified from a Uridine-Based Library: A Strategy to Inhibit O-Linked Glycosylation. Chem. Biol. 2002, 9, 113-129.
76. *Kiick, K. L.; *Saxon, E.; †Tirrell, D. A.; †Bertozzi, C. R. Incorporation of Azides into Recombinant Proteins for Chemoselective Modification by the Staudinger Ligation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 19-24.
75. Cook, B. N.; Bertozzi, C. R. Chemical Approaches to the Investigation of Cellular Systems. Bioorg. Med. Chem. 2002, 10, 829-840.
74. Marcaurelle, L. A.; Bertozzi, C. R. Recent Advances in the Chemical Synthesis of Mucin-Type Glycoproteins. Glycobiology 2002, 12, R69-R77.
73. Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Ouyang, Y.-B.; Moore, K. L.; Ellman, J. E.; Bertozzi, C. R. Tyrosylprotein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided Ligand Assembly. Bioorg. Med. Chem. Lett. 2002, 12, 329-332.
72. Nauman, D. A.; Bertozzi, C. R. Determination of Kinetic Parameters for Chemoselective Reaction with Cell-Surface Ketones: A Mathematical Model for Small-Molecule Drug Delivery. Biochim. Biophys. Acta. 2001, 1568, 147-154.
71. Sampson, N. S.; Mrksich, M.; Bertozzi, C. R. Surface Molecular Recognition. Proc. Natl. Acad. Sci. U.S.A 2001, 98, 12870-12871.
70. Marcaurelle, L. A.; Shin, Y.; Goon, S.; Bertozzi, C. R. Synthesis of Oxime-linked Mucin Mimics Containing the Tumor-related TN and Sialyl TN Antigens. Org. Lett. 2001, 3, 3691-3694.
69. Mahal, L. K.; Charter, N. W.; Angata, K.; Fukuda, M.; Koshland, D. E., Jr.; Bertozzi, C. R. A Small Molecule Modulator of Poly-a2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells. Science 2001, 294, 380-382.
68. Jacobs, C. L.; Goon, S.; Yarema, K. J.; Hinderlich, S.; Hang, H. C.; Chai, D. H.; Bertozzi, C. R. Substrate Specificity of the Sialic Acid Biosynthetic Pathway. Biochemistry 2001, 40, 12864-12874.
67. Saxon, E.; Bertozzi, C. R. Chemical and Biological Strategies for Engineering Cell Surface Glycosylation. Ann. Rev. Cell Dev. Biol. 2001, 17, 1-23.
66. Schilling, B.; Goon, S.; Samuels, N. M.; Gaucher, S. P.; Leary, J. A.; Bertozzi, C. R.; Gibson, B. W. Biosynthesis of Sialylated Lipooligosaccharides in Haemophilus ducreyi is Dependent on Exogenous Sialic Acid and not Mannosamine. Biochemistry 2001, 40, 12666-12677.
65. Bruehl, R. E.; Dasgupta, F.; Katsumoto, T. R.; Tan, J. H.; Bertozzi, C. R.; Spevak, W.; Ahn, D. J.; Rosen, S. D.; Nagy, J. O. Polymerized Liposome Assemblies: Bifunctional Macromolecular Selectin Inhibitors Mimicking Physiological Selectin Ligands. Biochemistry 2001, 40, 5964-5974.
64. Armstrong, J. I.; Ge, X.; Verdugo, D. E.; Winans, K. A.; Leary, J. A.; Bertozzi, C. R. A Library Approach to the Generation of Bisubstrate Analog Sulfotransferase Inhibitors. Org. Lett. 2001, 3, 2657-2660.
63. Verdugo, D. E.; Cancilla, M. T.; Ge, X.; Gray, N. S.; Chang, Y.-T.; Schultz, P. G.; Negishi, M.; Leary, J. A.; Bertozzi, C. R. Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen. J. Med. Chem., 2001, 44, 2683-2686.
62. Hang, H. C.; Bertozzi, C. R. Chemoselective Approaches to Glycoprotein Engineering. Accounts Chem. Res. 2001, 34, 727-736.
61. Groves, J. T.; Mahal, L. K.; Bertozzi, C. R. Control of Cell Adhesion and Growth with Micropatterned Supported Lipid Membranes. Langmuir 2001, 17, 5129-5133.
60. Yarema, K. J.; Goon, S.; Bertozzi, C. R. Metabolic Selection of Glycosylation Defects in Human Cells. Nature Biotechnol. 2001, 19, 553-558.
59. Yarema, K. J.; Bertozzi, C. R. Characterizing Glycosylation Pathways. Genome Biology 2001, 2, 0004.1-0004.10.
58. Lemieux, G. A.; Bertozzi, C. R. Modulating Cell Surface Immunoreactivity by Metabolic Induction of Unnatural Carbohydrate Antigens. Chem. Biol. 2001, 8, 265-275.
57. Bertozzi, C. R.; Kiessling, L. L. Chemical Glycobiology. Science 2001, 291, 2357-2364.
56. Marcaurelle, L. A.; Bertozzi, C. R. Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc. J. Am. Chem. Soc. 2001, 123, 1587-1595.
55. Marcaurelle, L. A.; Mizoue, L. S.; Wilken, J.; Oldham, L.; Kent, S. B. H.; Handel, T. M.; Bertozzi, C. R. Chemical Synthesis of Lymphotactin, a Glycosylated Chemokine with a C-terminal Mucin-like Domain. Chem. Eur. J. 2001, 7, 1129-1132.
54. Hang, H. C., Bertozzi, C. R. Ketone Isosteres of 2-N-Acetamidosugars as Substrates for Metabolic Cell Surface Engineering. J. Am. Chem. Soc. 2001, 123, 1242-1243.
53. Bowman, K. G.; Cook, B. N.; de Graffenried, C. L.; Bertozzi, C. R. Biosynthesis of L-selectin Ligands: Sulfation of Sialyl Lewis x-Related Oligosaccharides by a Family of GlcNAc-6-Sulfotransferases. Biochemistry 2001, 40, 5382-5391.
52. Bruehl, R. E.; Bertozzi, C. R.; Rosen, S. D. Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J. Biol. Chem. 2000, 275, 32642-32648.
51. Bhakta, S.; Bartes, A.; Bowman, K. G.; Kao, W.-M.; Polsky, I.; Lee, J. K.; Cook, B. N.; Bruehl, R.; Rosen, S. D.; Bertozzi, C. R.; Hemmerich, S. Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST5). J. Biol. Chem. 2000, 275, 40226-40234.
50. Macmillan, D.; Bertozzi, C. R. New Directions in Glycoprotein Engineering. Tetrahedron 2000, 56, 9515-9525.
49. Cook, B. N.; Bhakta, S.; Biegel, T.; Bowman, K. G.; Armstrong, J. I.; Hemmerich, S.; Bertozzi, C. R. Differential Carbohydrate Recognition of Two GlcNAc-6-Sulfotransferases with Possible Roles in L-Selectin Ligand Biosynthesis. J. Am. Chem. Soc. 2000, 122, 8612-8622.
48. Armstrong, J. I.; Bertozzi, C. R. Sulfotransferases as Targets for Therapeutic Intervention. Curr. Opin. Drug Disc. Dev. 2000, 3, 502-515.
47. *Charter, N. W.; *Mahal, L. K.; Koshland, D. E., Jr.; Bertozzi, C. R. Biosynthetic Incorporation of Unnatural Sialic Acids into Polysialic Acid on Neural Cells. Glycobiology, 2000, 10, 1-8.
46. Jacobs, C. J.; Yarema, K. J.; Mahal, L. K.; Nauman, D. A.; Charters, N.; Bertozzi, C. R. Metabolic Labeling of Glycoproteins with Chemical Tags through Unnatural Sialic Acid Biosynthesis. Meth. Enzymol. 2000, 327, 260-275.
45. Saxon, E.; Armstrong, J. I.; Bertozzi, C. R. A “Traceless” Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds. Org. Lett. 2000, 2, 2141-2143.
44. Saxon, E.; Bertozzi, C. R. Cell Surface Engineering by a Modified Staudinger Reaction. Science 2000, 287, 2007-2010.
43. Armstrong, J. I.; Portley, A. R.; Chang, Y.-T.; Nierengarten, D. M.; Cook, B. N.; Bowman, K. G.; Bishop, A.; Gray, N. S.; Shokat, K. M.; Schultz, P. G.; Bertozzi, C. R. Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library. Angew. Chem., Int. Ed. 2000, 39, 1303-1306.
42. Kehoe, J. W.; Bertozzi, C. R. Tyrosine Sulfation: A Modulator of Extracellular Protein-Protein Interactions. Chem. Biol. 2000, 7, R57-R61.
41. Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R. Fmoc-Based Synthesis of Peptide-aThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation. J. Am. Chem. Soc. 1999, 121, 11684-11689.
40. Mahal, L. K.; Yarema, K. J.; Lemieux, G. A.; Bertozzi, C. R. Chemical Approaches to Glycobiology: Engineering Cell Surface Sialic Acids for Tumor Targeting, in Sialobiology and Other Novel Forms of Glycosylation, Inoue, Y.; Lee, Y. C.; Troy, F. A., III, eds. Gakushin Publishing Company: Osaka, 1999, pp. 237-280.
39. Winans, K. A.; King, D. A.; Rao, V.; Bertozzi, C. R. A Chemically Synthesized Version of the Insect Antibacterial Glycopeptide, Diptericin, Disrupts Bacterial Membrane Integrity. Biochemistry 1999, 38, 11700-11710.
38. Lee, J. H.; Baker, T. J.; Mahal, L. K.; Zabner, J.; Bertozzi, C. R.; Wiemer, D. F.; Welsh, M. J. Engineering Novel Cell Surface Receptors for Virus-Mediated Gene Transfer. J. Biol. Chem. 1999, 274, 21878-21884.
37. Lemieux, G. A.; Yarema, K. J.; Jacobs, C. L.; Bertozzi, C. R. Exploiting Differences in Sialoside Expression for Selective Targeting of MRI Contrast Reagents. J. Am. Chem. Soc. 1999, 121, 4278-4279.
36. Marcaurelle, L. A.; Bertozzi, C. R. New Directions in the Synthesis of Glycopeptide Mimetics. Chem. Eur. J. 1999, 5, 1384-1390.
35. Chen, Q.; Zhang, D.; Somorjai, G.; Bertozzi, C. R. Probing the Surface Structural Rearrangement of Hydrogels by Sum-Frequency Generation Spectroscopy. J. Am. Chem. Soc. 1999, 121, 446-447.
34. Bowman, K. G.; Bertozzi, C. R. Carbohydrate Sulfotransferases: Mediators of Extracellular Communication. Chem. Biol. 1999, 6, R9-R22.
33. Winans, K. A.; Bertozzi, C. R. Inner Space Exploration: The Chemical Biologist’s Guide to the Cell. Chem. Biol. 1998, 5, R313-R315.
32. Yarema, K. J.; Mahal, L. K.; Bruehl, R.; Rodriguez, E. C.; Bertozzi, C. R. Metabolic Delivery of Ketone Groups to Sialic Acid Residues. Application to Cell Surface Glycoform Engineering. J. Biol. Chem. 1998, 273, 31168-31179.
31. Marcaurelle, L. A.; Rodriguez, E. C.; Bertozzi, C. R. Synthesis of an Oxime-Linked Neoglycopeptide with Glycosylation-Dependent Activity Similar to its Native Counterpart. Tetrahedron Lett. 1998, 39, 8417-8420.
30. Rodriguez, E. C.; Marcaurelle, L. A.; Bertozzi, C. R. Aminooxy, Hydrazide and Thiosemicarbazide-Functionalized Saccharides: Versatile Reagents for Glycoconjugate Synthesis. J. Org. Chem. 1998, 63, 7134-7135.
29. Marcaurelle, L. A.; Bertozzi, C. R. Direct Incorporation of Unprotected Ketone Groups into Peptides During Solid-Phase Synthesis: Application to the One-Step Synthesis of Peptides with Two Different Biophysical Probes for FRET. Tetrahedron Lett. 1998, 39, 7279-7282.
28. Bowman, K. G.; Hemmerich, S.; Bhakta, S.; Singer, M. S.; Rosen, S. D.; Bertozzi, C. R. Identification of an N-Acetylglucosamine-6-O-Sulfotransferase Activity Restricted to Lymphoid Tissue: An Enzyme with a Possible Role in Lymphocyte Homing. Chem. Biol. 1998, 5, 447-460.
27. Lemieux, G. A. ; Bertozzi, C. R. Chemoselective Ligation Reactions with Proteins, Oligosaccharides and Cells. Trends Biotech. 1998, 16, 506-513.
26. Yarema, K. J.; Bertozzi, C. R. Chemical Approaches to Glycobiology and Emerging Carbohydrate-Based Therapeutic Agents. Curr. Opin. Chem. Biol. 1998, 2, 49-61.
25. Rodriguez, E. C.; Winans, K. A.; King, D. S.; Bertozzi, C. R. A Strategy for the Chemoselective Synthesis of O-Linked Glycopeptides with Native Sugar-Peptide Linkages. J. Am. Chem. Soc. 1997, 119, 9905-9906.
24. Mahal, L. K.; Bertozzi, C. R. Engineered Cell Surfaces: Fertile Ground for Molecular Landscaping. Chem. Biol. 1997, 4, 415-422.
23. Mahal, L. K.; Yarema, K. J.; Bertozzi, C. R. Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis. Science 1997, 276, 1125-1128.
22. Bertozzi, C. R.; Singer, M. S.; Rosen, S. D. An ELISA for Selectin Inhibitors Based on Binding to a Physiological Ligand. J. Immunol. Meth. 1997, 203, 157-165.
21. Sanders, W. J.; Katsumoto, T. R.; Bertozzi, C. R.; Rosen, S. D.; Kiessling, L. L. L-Selectin-Carbohydrate Interactions: An Investigation into the Relevant Modifications of the Lewis x Trisaccharide. Biochemistry 1996, 35, 14862-14867.
20. Roe, B. A.; Boojamra, D. G.; Griggs, J.; Bertozzi, C. R. Synthesis of beta-C-Glycosides of N-acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups. J. Org. Chem. 1996, 61, 6442-6445.
19. Manning, D. D.; Bertozzi, C. R.; Rosen, S. D.; Kiessling, L. L. Tin Mediated Phosphorylation: Synthesis and Selectin Binding of a Phospho Lewis a Analog. Tetrahedron Lett. 1996, 37, 1953-1956.
18. Rosen, S. D.; Bertozzi, C. R. Leukocyte Adhesion: Two Selectins Converge on Sulphate. Current Biol. 1996, 6, 261-264.
17. Kobertz, W. R.; Bertozzi, C. R.; Bednarski, M. D. C-Glycosyl Aldehydes: Synthons for C-linked Disaccharides. J. Org. Chem. 1996, 61, 1894-1897.
16. Bertozzi, C. R.; Bednarski, M. D. “Synthesis of C-Glycosides: Stable Mimics of O-Glycosidic Linkages” in Modern Methods in Carbohydrate Synthesis, Khan, S. H.; O’Neill, R. A., eds. Harwood Academic Publishers GmbH: Amsterdam, 1996, pp 316-351.
15. Bertozzi, C. R. Cracking the Carbohydrate Code for Selectin Recognition. Chem. Biol. 1995, 2, 703-708.
14. Bertozzi, C. R.; Fukuda, S.; Rosen, S. D. Sulfated Disaccharide Inhibitors of L-Selectin: Deriving Structural Leads from a Physiological Selectin Ligand. Biochemistry 1995, 34, 14271-14278.
13. Manning, D. D.; Bertozzi, C. R.; Pohl, N. L.; Rosen, S. D.; Kiessling, L. L. Selectin-Saccharide Interactions: Revealing Structure-Activity Relationships with Total Synthesis. J. Org. Chem. 1995, 60, 6254-6255.
12. Rosen, S. D.; Bertozzi, C. R. The Selectins and Their Ligands. Curr. Opin. Cell Biol. 1994, 6, 663-673.
11. Hemmerich, S.; Bertozzi, C. R.; Leffler, H.; Rosen, S. D. Identification of the Sulfated Monosaccharides of GlyCAM-1, an Endothelial-Derived Ligand for L-Selectin. Biochemistry 1994, 33, 4820-4829.
10. Grabowski, J. J.; Bertozzi, C. R.; Jacobsen, J. R.; Jain, A.; Marzluff, E. M.; Suh, A. Y. Fluorescence Probes in Biochemistry: An Examination of the Non-Fluorescent Behavior of Dansylamide by Photoacoustic Calorimetry. Analytical Biochem. 1992, 207, 214-226.
9. Bertozzi, C. R.; Cook, D. G.; Kobertz, W. R.; Gonzalez-Scarano, F.; Bednarski, M. D. Carbon-Linked Galactosphingolipid Analogs Bind Specifically to HIV-1 gp120. J. Am. Chem. Soc. 1992, 114, 10639-10641.
8. Bertozzi, C. R.; Hoeprich, P. D., Jr.; Bednarski, M. D. Synthesis of Carbon-Linked Glycopeptides as Stable Glycopeptide Models. J. Org. Chem. 1992, 57, 6092-6094.
7. Bertozzi, C. R.; Bednarski, M. D. The Synthesis of 2-Azido C-Glycosyl Sugars. Tetrahedron Lett. 1992, 33, 3109-3112.
6. Bertozzi, C. R.; Bednarski, M. D. A Receptor-Mediated Immune Response Using Synthetic Glycoconjugates. J. Am. Chem. Soc. 1992, 114, 5543-5546.
5. Bertozzi, C. R.; Bednarski, M. D. Antibody Targeting to Bacterial Cells Using Receptor-Specific Ligands. J. Am. Chem. Soc. 1992, 114, 2242-2245.
4. Kobertz, W. R.; Bertozzi, C. R.; Bednarski, M. D. An Efficient Method for the Synthesis of alpha- and beta-C-Glycosyl Aldehydes. Tetrahedron Lett. 1992, 33, 737-740.
3. Bertozzi, C. R.; Bednarski, M. D. C-Glycosyl Compounds Bind to Receptors on the Surface of Escherichia coli and can Target Proteins to the Organism. Carbohydrate Res. 1992, 223, 243-253.
2. Bertozzi, C. R.; Bednarski, M. D. The Synthesis of Heterobifunctional Linkers for the Conjugation of Ligands to Molecular Probes. J. Org. Chem. 1991, 56, 4326-4329.
1. Chidsey, C. E. D.; Bertozzi, C. R.; Putvinski, T. M.; Mujsce, A. M. Coadsorption of Ferrocene-Terminated and Unsubstituted Alkanethiols on Gold: Electroactive Self-Assembled Monolayers. J. Am. Chem. Soc. 1990, 112, 4301-4306.
Books & Chapters
- Wang, P. G.; Bertozzi, C. R., Eds. Glycochemistry. Principles, Synthesis and Applications. Marcel Dekker, Inc.: New York, 2001.
- Varki, A.; Cummings, R. D.; Esko, J. D.; Freeze, H. H.; Stanley, P.; Bertozzi, C. R.; Hart, G. W.; Etzler, M. E., Eds. Essentials of Glycobiology, Second Edition. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 2009.
- Beahm, B. J.; Bertozzi, C. R. “Imaging Cell-Surface Glycans in Animals with Bioorthogonal Chemistry.” Glycoscience: Biology and Medicine. Ed. Endo, T.; Seeberger, P. H.; Hart, G. W.; Wong, C-H.; Taniguchi, T. Japan: Springer, 2014.1-11.