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Osteoarthritis is the most common form of arthritis, and pain is its defining symptom. Osteoarthritis is a complex disease whose etiology bridges biomechanics and biochemistry. Available treatment options, of which NSAIDs are the most common, often provide inadequate relief and are associated with health risks when used long term.
Evidence is growing for the role of systemic factors (such as genetics, dietary intake, estrogen use, and bone density) and of local biomechanical factors (such as muscle weakness, obesity, and joint laxity). Clinical investigations are uncovering the correlation with structural changes in the joint and insights into the efficacy of new analgesics and the pathophysiology of OA pain.
Treating Osteoarthritis Today
B. Todd Sitzman, MD
Where vs Why: Central Contributions to Regional Pain Conditions
Roger B. Fillingim, PhD
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