Nobel Laureate
Professor Emerita, Biochemistry and Biophysics , 9th Annual Lindahl Lecture
Throughout her long career in science, Dr. Blackburn has been a leader in the area of telomere and telomerase research, having discovered the molecular nature of telomeres – the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information – and co-discovered the ribonucleoprotein enzyme, telomerase. She is also known for her championing of diversity and inclusion in the sciences. Currently, Dr. Blackburn and her UCSF research team continue their work with various cells (including human cells), with the goal of understanding telomerase and telomere biology. She and her research team also collaborate in a wide range of investigations of the roles of telomere biology in human health and diseases, through clinical and other human studies.
Born in Australia, Dr. Blackburn earned her B.Sc. and M.Sc. degrees from the University of Melbourne, and her Ph.D. from the University of Cambridge in England. She was a postdoctoral fellow in the Molecular and Cellular Biology Department at Yale University. Professor Blackburn has won many prestigious awards throughout her career including Nobel Prize in Physiology or Medicine, the Albert Lasker Medical Research Award for Basic Medical Research, and in 2007 was named one of TIME Magazine’s 100 Most Influential People.
Sessions at Neurovations Events
- 9th Annual Lindahl Lecture
Awards
- The Nobel Prize in Physiology or Medicine 2009
- 2021 Lindahl Lecture
- Albert Lasker Medical Research Award for Basic Medical Research
- 2007 TIME Magazine’s 100 Most Influential People
Select Publications
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Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study. Am J Psychiatry. 2021 02 01; 178(2):183-192. Verner G, Epel E, Lahti-Pulkkinen M, Kajantie E, Buss C, Lin J, Blackburn E, Räikkönen K, Wadhwa PD, Entringer S. PMID: 32911996.
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Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation. Brain Behav Immun. 2019 08; 80:419-426. Lazarides C, Epel ES, Lin J, Blackburn EH, Voelkle MC, Buss C, Simhan HN, Wadhwa PD, Entringer S. PMID: 30974172.
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An investigation of racial/ethnic and sex differences in the association between experiences of everyday discrimination and leukocyte telomere length among patients with coronary artery disease. Psychoneuroendocrinology. 2019 08; 106:122-128. Sullivan S, Hammadah M, Al Mheid I, Shah A, Sun YV, Kutner M, Ward L, Blackburn E, Zhao J, Lin J, Bremner JD, Quyyumi AA, Vaccarino V, Lewis TT. PMID: 30978531.
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Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat Commun. 2018 09 04; 9(1):3583. Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH. PMID: 30181605.
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In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study. Psychoneuroendocrinology. 2018 10; 96:179-187. Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E. PMID: 29980010.
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Chronic Obesity and Incident Hypertension in Latina Women Are Associated with Accelerated Telomere Length Loss over a 1-Year Period. Metab Syndr Relat Disord. 2018 08; 16(6):262-266. Wojcicki JM, Elwan D, Lin J, Blackburn E, Epel E. PMID: 29750592.
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Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults. Neurobiol Aging. 2018 09; 69:68-75. Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH. PMID: 29859365.
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Validation of Minimally-Invasive Sample Collection Methods for Measurement of Telomere Length. Front Aging Neurosci. 2017; 9:397. Stout SA, Lin J, Hernandez N, Davis EP, Blackburn E, Carroll JE, Glynn LM. PMID: 29270121.View in: PubMed
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Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men. J Racial Ethn Health Disparities. 2018 06; 5(3):459-467. Schrock JM, Adler NE, Epel ES, Nuru-Jeter AM, Lin J, Blackburn EH, Taylor RJ, Chae DH. PMID: 28634877.
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Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings. J Psychosom Res. 2017 08; 99:177-180. Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM. PMID: 28712425.
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The Longitudinal Relationship Between Cortisol Responses to Mental Stress and Leukocyte Telomere Attrition. J Clin Endocrinol Metab. 2017 03 01; 102(3):962-969. Steptoe A, Hamer M, Lin J, Blackburn EH, Erusalimsky JD. PMID: 27967317.
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Correction: Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. PLoS One. 2016; 11(12):e0168868. Goglin SE, Farzaneh-Far R, Epel ES, Lin J, Blackburn EH, Whooley MA. PMID: 27992608.
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Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults. PLoS Med. 2016 Nov; 13(11):e1002188. Rehkopf DH, Needham BL, Lin J, Blackburn EH, Zota AR, Wojcicki JM, Epel ES. PMID: 27898678.
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Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. PLoS One. 2016; 11(10):e0160748. Goglin SE, Farzaneh-Far R, Epel ES, Lin J, Blackburn EH, Whooley MA. PMID: 27783614.
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Leukocyte telomere length and ideal cardiovascular health in American Indians: the Strong Heart Family Study. Eur J Epidemiol. 2017 01; 32(1):67-75. Peng H, Mete M, Desale S, Fretts AM, Cole SA, Best LG, Lin J, Blackburn E, Lee ET, Howard BV, Zhao J. PMID: 27660162.
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HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis. PLoS One. 2016; 11(9):e0163153. Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L. PMID: 27655116.
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Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects. Viruses. 2016 08 11; 8(8). Usadi B, Bruhn R, Lin J, Lee TH, Blackburn E, Murphy EL. PMID: 27529270.
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Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study. Aging (Albany NY). 2016 08; 8(8):1583-92. Peng H, Zhu Y, Yeh F, Cole SA, Best LG, Lin J, Blackburn E, Devereux RB, Roman MJ, Lee ET, Howard BV, Zhao J. PMID: 27540694.
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Early exclusive breastfeeding is associated with longer telomeres in Latino preschool children. Am J Clin Nutr. 2016 08; 104(2):397-405. Wojcicki JM, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E. PMID: 27440083.
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Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins. Mol Cell Biol. 2016 07 15; 36(14):1908-19. Jay KA, Smith DL, Blackburn EH. PMID: 27161319.
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Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report. Mol Neuropsychiatry. 2016 Jul; 2(2):88-96. Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM. PMID: 27429957.View in: PubMed
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Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change. Mol Genet Genomics. 2016 Jun; 291(3):1379-89. Wojcicki JM, Shiboski S, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E. PMID: 26965507.
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Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes. J Immunol Res. 2016; 2016:5371050. Lin J, Cheon J, Brown R, Coccia M, Puterman E, Aschbacher K, Sinclair E, Epel E, Blackburn EH. PMID: 26977417.
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The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo. PeerJ. 2016; 4:e1534. Matsuguchi T, Blackburn E. PMID: 27004145.View in: PubMed Mentions:
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Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prev Res (Phila). 2016 Jan; 9(1):2-10. Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM. PMID: 26744449.
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Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science. 2015 Dec 04; 350(6265):1193-8. Blackburn EH, Epel ES, Lin J. PMID: 26785477.
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Movement-Based Behaviors and Leukocyte Telomere Length among US Adults. Med Sci Sports Exerc. 2015 Nov; 47(11):2347-52. Loprinzi PD, Loenneke JP, Blackburn EH. PMID: 25970659.
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Association of dimensional psychological health measures with telomere length in male war veterans. J Affect Disord. 2016 Jan 15; 190:537-542. Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM. PMID: 26571103.
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Q&A: End-game winner. Nature. 2015 Oct 22; 526(7574):S56-7. Blackburn E, Tucker E. PMID: 26488243.
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Discrimination, mental health, and leukocyte telomere length among African American men. Psychoneuroendocrinology. 2016 Jan; 63:10-6. Chae DH, Epel ES, Nuru-Jeter AM, Lincoln KD, Taylor RJ, Lin J, Blackburn EH, Thomas SB. PMID: 26398001.
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Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002. Epidemiology. 2015 Jul; 26(4):528-35. Needham BL, Rehkopf D, Adler N, Gregorich S, Lin J, Blackburn EH, Epel ES. PMID: 26039272.
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Mitochondrial DNA copy number is reduced in male combat veterans with PTSD. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 04; 64:10-7. Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH. PMID: 26120081.
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Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug; 200(4):1061-72. Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH. PMID: 26092717.
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Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length. Ann Nutr Metab. 2015; 66(4):202-8. Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Shahbaba B, Gillen DL, Venkataramanan R, Simhan HN, Wadhwa PD. PMID: 26067849.
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Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging. Neurosci Biobehav Rev. 2015 Aug; 55:333-64. Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM. PMID: 25999120.
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Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample. J Health Soc Behav. 2015 Jun; 56(2):199-224. Geronimus AT, Pearson JA, Linnenbringer E, Schulz AJ, Reyes AG, Epel ES, Lin J, Blackburn EH. PMID: 25930147.
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Early telomerase inactivation accelerates aging independently of telomere length. Cell. 2015 Feb 26; 160(5):928-939. Xie Z, Jay KA, Smith DL, Zhang Y, Liu Z, Zheng J, Tian R, Li H, Blackburn EH. PMID: 25723167.
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PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression. Psychiatry Res. 2015 Apr 30; 232(1):58-64. Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S. PMID: 25773002.
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Maternal estriol concentrations in early gestation predict infant telomere length. J Clin Endocrinol Metab. 2015 Jan; 100(1):267-73. Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Simhan HN, Wadhwa PD. PMID: 25337925.
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Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis. J Mol Biol. 2015 Apr 24; 427(8):1728-47. Fraser JA, Worrall EG, Lin Y, Landre V, Pettersson S, Blackburn E, Walkinshaw M, Muller P, Vojtesek B, Ball K, Hupp TR. PMID: 25543083.
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Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women. Brain Behav Immun. 2015 Jul; 47:155-62. Prather AA, Gurfein B, Moran P, Daubenmier J, Acree M, Bacchetti P, Sinclair E, Lin J, Blackburn E, Hecht FM, Epel ES. PMID: 25535858.
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Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002. Am J Epidemiol. 2015 Jan 15; 181(2):127-36. Zota AR, Needham BL, Blackburn EH, Lin J, Park SK, Rehkopf DH, Epel ES. PMID: 25504027.
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Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1026-32. Roberts JD, Dewland TA, Longoria J, Fitzpatrick AL, Ziv E, Hu D, Lin J, Glidden DV, Psaty BM, Burchard EG, Blackburn EH, Olgin JE, Heckbert SR, Marcus GM. PMID: 25381796.
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Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys. Am J Public Health. 2014 Dec; 104(12):2425-31. Leung CW, Laraia BA, Needham BL, Rehkopf DH, Adler NE, Lin J, Blackburn EH, Epel ES. PMID: 25322305.
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An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. Blood. 2014 Dec 11; 124(25):3675-84. Gazzaniga FS, Blackburn EH. PMID: 25320237.
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Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. J Affect Disord. 2014 Dec; 169:86-90. Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM. PMID: 25173430.
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Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging. JAMA Neurol. 2014 Jul 01; 71(7):921-3. Jacobs EG, Epel ES, Lin J, Blackburn EH, Rasgon NL. PMID: 25023551.
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Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: the Strong Heart Family Study. Aging (Albany NY). 2014 May; 6(5):414-27. Chen S, Lin J, Matsuguchi T, Blackburn E, Yeh F, Best LG, Devereux RB, Lee ET, Howard BV, Roman MJ, Zhao J. PMID: 24902894.
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Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany NY). 2014 May; 6(5):380-9. Chen S, Yeh F, Lin J, Matsuguchi T, Blackburn E, Lee ET, Howard BV, Zhao J. PMID: 24861044.
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Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4519-24. Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A. PMID: 24616496.
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Metabolic profiles of biological aging in American Indians: the Strong Heart Family Study. Aging (Albany NY). 2014 Mar; 6(3):176-86. Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV. PMID: 24799415.
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Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study. Am J Hum Biol. 2014 May-Jun; 26(3):367-75. Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH. PMID: 24615938.
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Discrimination, racial bias, and telomere length in African-American men. Am J Prev Med. 2014 Feb; 46(2):103-11. Chae DH, Nuru-Jeter AM, Adler NE, Brody GH, Lin J, Blackburn EH, Epel ES. PMID: 24439343.
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Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite. 2014 May; 76:84-94. Buss J, Havel PJ, Epel E, Lin J, Blackburn E, Daubenmier J. PMID: 24462487.
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Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013 Dec 19; 155(7):1479-91. Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B. PMID: 24360272.
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Q&A: Elizabeth Blackburn on telomerase and tumors. Cancer Discov. 2013 Dec; 3(12):1323. Blackburn E. PMID: 24327681.
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An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. Mol Cell Biol. 2014 Jan; 34(2):280-9. Listerman I, Gazzaniga FS, Blackburn EH. PMID: 24216762.
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Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013 Oct; 14(11):1112-1120. Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJM, Daubenmier J, Estay I, Hills NK, Chainani-Wu N, Carroll PR, Blackburn EH. PMID: 24051140.
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QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study. Aging (Albany NY). 2013 Sep; 5(9):704-16. Zhu Y, Voruganti VS, Lin J, Matsuguchi T, Blackburn E, Best LG, Lee ET, MacCluer JW, Cole SA, Zhao J. PMID: 24036517.
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Longer leukocyte telomere length in Costa Rica’s Nicoya Peninsula: a population-based study. Exp Gerontol. 2013 Nov; 48(11):1266-73. Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH. PMID: 23988653.
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Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study. Diabetes. 2014 Jan; 63(1):354-62. Zhao J, Zhu Y, Lin J, Matsuguchi T, Blackburn E, Zhang Y, Cole SA, Best LG, Lee ET, Howard BV. PMID: 23949319.
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Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study. Brain Behav Immun. 2013 Oct; 33:65-73. Puterman E, Epel ES, Lin J, Blackburn EH, Gross JJ, Whooley MA, Cohen BE. PMID: 23727245.
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The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Res. 2013 May 01; 73(9):2817-28. Listerman I, Sun J, Gazzaniga FS, Lukas JL, Blackburn EH. PMID: 23610451.
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Visualization of actin filaments and monomers in somatic cell nuclei. Mol Biol Cell. 2013 Apr; 24(7):982-94. Belin BJ, Cimini BA, Blackburn EH, Mullins RD. PMID: 23447706.
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Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002. Soc Sci Med. 2013 May; 85:1-8. Needham BL, Adler N, Gregorich S, Rehkopf D, Lin J, Blackburn EH, Epel ES. PMID: 23540359.
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Accelerated cell aging in female APOE-e4 carriers: implications for hormone therapy use. PLoS One. 2013; 8(2):e54713. Jacobs EG, Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL. PMID: 23418430.
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Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort. Exp Gerontol. 2013 Apr; 48(4):385-90. Dowd JB, Bosch JA, Steptoe A, Blackburn EH, Lin J, Rees-Clayton E, Aiello AE. PMID: 23403382.
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Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. Am J Obstet Gynecol. 2013 Feb; 208(2):134.e1-7. Entringer S, Epel ES, Lin J, Buss C, Shahbaba B, Blackburn EH, Simhan HN, Wadhwa PD. PMID: 23200710.
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Association between kidney function and telomere length: the heart and soul study. Am J Nephrol. 2012; 36(5):405-11. Bansal N, Whooley MA, Regan M, McCulloch CE, Ix JH, Epel E, Blackburn E, Lin J, Hsu CY. PMID: 23108000.
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Telomeres and adversity: Too toxic to ignore. Nature. 2012 Oct 11; 490(7419):169-71. Blackburn EH, Epel ES. PMID: 23060172.
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Chronic stress elevates telomerase activity in rats. Biol Lett. 2012 Dec 23; 8(6):1063-6. Beery AK, Lin J, Biddle JS, Francis DD, Blackburn EH, Epel ES. PMID: 23054915.
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Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun. 2013 Feb; 28:16-24. Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. PMID: 23010452.
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The telomere syndromes. Nat Rev Genet. 2012 Oct; 13(10):693-704. Armanios M, Blackburn EH. PMID: 22965356.
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Educational attainment and late life telomere length in the Health, Aging and Body Composition Study. Brain Behav Immun. 2013 Jan; 27(1):15-21. Adler N, Pantell MS, O’Donovan A, Blackburn E, Cawthon R, Koster A, Opresko P, Newman A, Harris TB, Epel E. PMID: 22981835.
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Socioeconomic status and cell aging in children. Soc Sci Med. 2012 Jun; 74(12):1948-51. Needham BL, Fernandez JR, Lin J, Epel ES, Blackburn EH. PMID: 22472277.
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Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain Behav Immun. 2012 May; 26(4):573-9. O’Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES. PMID: 22293459.
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Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology. 2012 Jul; 37(7):917-28. Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E. PMID: 22169588.
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Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav. 2012 Apr 12; 106(1):40-5. Tomiyama AJ, O’Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E. PMID: 22138440.
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Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study. Atherosclerosis. 2012 Feb; 220(2):506-12. Kroenke CH, Pletcher MJ, Lin J, Blackburn E, Adler N, Matthews K, Epel E. PMID: 22178426.
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Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study. PLoS One. 2011; 6(11):e26983. Krauss J, Farzaneh-Far R, Puterman E, Na B, Lin J, Epel E, Blackburn E, Whooley MA. PMID: 22096513.
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Shorter leukocyte telomere length in midlife women with poor sleep quality. J Aging Res. 2011; 2011:721390. Prather AA, Puterman E, Lin J, O’Donovan A, Krauss J, Tomiyama AJ, Epel ES, Blackburn EH. PMID: 22046530.View in: PubMed
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Hostility and cellular aging in men from the Whitehall II cohort. Biol Psychiatry. 2012 May 01; 71(9):767-73. Brydon L, Lin J, Butcher L, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A. PMID: 21974787.
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Actuary of the cell. Interview by Thea Singer. Sci Am. 2011 Oct; 305(4):84-7. Blackburn EH. PMID: 22106813.
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Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children. Psychosom Med. 2011 Sep; 73(7):533-40. Kroenke CH, Epel E, Adler N, Bush NR, Obradovic J, Lin J, Blackburn E, Stamperdahl JL, Boyce WT. PMID: 21873585.
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Telomeres and lifestyle factors: roles in cellular aging. Mutat Res. 2012 Feb 01; 730(1-2):85-9. Lin J, Epel E, Blackburn E. PMID: 21878343.
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Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res. 2011 Nov 01; 39(20):e134. Aviv A, Hunt SC, Lin J, Cao X, Kimura M, Blackburn E. PMID: 21824912.
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Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):E513-8. Entringer S, Epel ES, Kumsta R, Lin J, Hellhammer DH, Blackburn EH, Wüst S, Wadhwa PD. PMID: 21813766.
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Cancer interception. Cancer Prev Res (Phila). 2011 Jun; 4(6):787-92. Blackburn EH. PMID: 21636545.
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Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study. Psychosom Med. 2011 Sep; 73(7):541-7. Hoen PW, de Jonge P, Na BY, Farzaneh-Far R, Epel E, Lin J, Blackburn E, Whooley MA. PMID: 21597035.
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Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One. 2011; 6(5):e19687. O’Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES, . PMID: 21602933.
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Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol. 2011 May 01; 3(5). Blackburn EH, Collins K. PMID: 20660025.
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Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women. Brain Behav Immun. 2011 Oct; 25(7):1292-8. Steptoe A, Hamer M, Butcher L, Lin J, Brydon L, Kivimäki M, Marmot M, Blackburn E, Erusalimsky JD. PMID: 21536122.
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Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry. 2011 Sep 01; 70(5):465-71. O’Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S, Metzler T, Lenoci M, Blackburn E, Neylan TC. PMID: 21489410.
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Walking the walk from genes through telomere maintenance to cancer risk. Cancer Prev Res (Phila). 2011 Apr; 4(4):473-5. Blackburn EH. PMID: 21460394.
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Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress–preliminary findings. PLoS One. 2011 Mar 23; 6(3):e17837. Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH. PMID: 21448457.
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Telomere shortening in formerly abused and never abused women. Biol Res Nurs. 2012 Apr; 14(2):115-23. Humphreys J, Epel ES, Cooper BA, Lin J, Blackburn EH, Lee KA. PMID: 21385798.
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Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011 Jun; 36(5):664-81. Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD. PMID: 21035949.
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Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline. Brain Res. 2011 Mar 16; 1379:224-31. Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL. PMID: 20965155.
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Telomeres and telomerase: the means to the end (Nobel lecture). Angew Chem Int Ed Engl. 2010 Oct 04; 49(41):7405-21. Blackburn EH. PMID: 20821774.
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A common variant in the telomerase RNA component is associated with short telomere length. PLoS One. 2010 Sep 27; 5(9):e13048. Njajou OT, Blackburn EH, Pawlikowska L, Mangino M, Damcott CM, Kwok PY, Spector TD, Newman AB, Harris TB, Cummings SR, Cawthon RM, Shuldiner AR, Valdes AM, Hsueh WC. PMID: 20885959.
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A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53. J Biol Chem. 2010 Nov 26; 285(48):37773-86. Fraser JA, Madhumalar A, Blackburn E, Bramham J, Walkinshaw MD, Verma C, Hupp TR. PMID: 20847049.
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Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site. J Biol Chem. 2010 Nov 12; 285(46):35814-24. Williams TL, Levy DL, Maki-Yonekura S, Yonekura K, Blackburn EH. PMID: 20826803.
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The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. Mol Cell. 2010 Jul 30; 39(2):307-14. Stohr BA, Xu L, Blackburn EH. PMID: 20670897.
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The power of exercise: buffering the effect of chronic stress on telomere length. PLoS One. 2010 May 26; 5(5):e10837. Puterman E, Lin J, Blackburn E, O’Donovan A, Adler N, Epel E. PMID: 20520771.
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Highlighting the science of cancer prevention. Cancer Prev Res (Phila). 2010 Apr; 3(4):393. Blackburn EH. PMID: 20354167.
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Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila). 2010 Apr; 3(4):394-402. Blackburn EH, Tlsty TD, Lippman SM. PMID: 20354163.
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Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA. 2010 Jan 20; 303(3):250-7. Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA. PMID: 20085953.
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Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One. 2010 Jan 08; 5(1):e8612. Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA. PMID: 20072607.
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Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun. 2010 May; 24(4):531-9. Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, Blackburn EH. PMID: 20018236.
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2009 Nobels: break or breakthrough for women? Interview by Jeffrey Mervis and Kate Travis. Science. 2009 Oct 30; 326(5953):656-8. Blackburn E, Greider C, Yonath A, Ostrom E. PMID: 19900910.
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Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods. 2010 Jan 31; 352(1-2):71-80. Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E. PMID: 19837074.
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Telomeres and Tetrahymena: an interview with Elizabeth Blackburn. Dis Model Mech. 2009 Nov-Dec; 2(11-12):534-7. Blackburn E. PMID: 19841239.
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DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat Cell Biol. 2009 Nov; 11(11):1383-6. Makovets S, Blackburn EH. PMID: 19838171.
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Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres. Ann N Y Acad Sci. 2009 Aug; 1172:34-53. Epel E, Daubenmier J, Moskowitz JT, Folkman S, Blackburn E. PMID: 19735238.
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Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2009 Aug; 64(8):860-4. Njajou OT, Hsueh WC, Blackburn EH, Newman AB, Wu SH, Li R, Simonsick EM, Harris TM, Cummings SR, Cawthon RM. PMID: 19435951.
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A conversation with Elizabeth Blackburn. Interview by Misia Landau. Clin Chem. 2009 Apr; 55(4):835-41. Blackburn E. PMID: 19233908.
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Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 2009 Jan 09; 136(1):50-61. Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH. PMID: 19135888.
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Mec1 function in the DNA damage response does not require its interaction with Tel2. . 2008 Dec; 7(23):3695-8. Anderson CM, Blackburn EH. PMID: 19029808.View in: PubMed
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The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY). 2008 Dec 04; 1(1):81-8. Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ, Seeman TE. PMID: 20195384.
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Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy. Epigenetics Chromatin. 2008 Oct 27; 1(1):4. Wang X, Kam Z, Carlton PM, Xu L, Sedat JW, Blackburn EH. PMID: 19014413.
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Dietary restraint and telomere length in pre- and postmenopausal women. Psychosom Med. 2008 Oct; 70(8):845-9. Kiefer A, Lin J, Blackburn E, Epel E. PMID: 18923062.
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Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol. 2008 Nov; 9(11):1048-57. Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH. PMID: 18799354.
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A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response. Mol Cell Biol. 2008 Sep; 28(18):5736-46. Seidel JJ, Anderson CM, Blackburn EH. PMID: 18625723.
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ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008 Jul 01; 68(13):5309-17. Stohr BA, Blackburn EH. PMID: 18593932.
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Interview with Elizabeth Blackburn, Ph.D. Interview by Vicki Glaser. Rejuvenation Res. 2008 Jun; 11(3):701-5. Blackburn E. PMID: 18593291.
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Elizabeth Blackburn: because science is worth it. Interview by Ruth Williams. J Cell Biol. 2008 Mar 24; 180(6):1056-7. Blackburn E. PMID: 18362176.
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Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev. 2008 Apr 01; 22(7):854-9. Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, Blackburn EH. PMID: 18334620.
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The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase. Genetics. 2008 Jan; 178(1):245-57. Makovets S, Williams TL, Blackburn EH. PMID: 18202371.
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Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell. 2007 Oct 26; 28(2):315-27. Xu L, Blackburn EH. PMID: 17964269.
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Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12135-9. Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, Hsueh WC. PMID: 17623782.
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Telomerase core components protect Candida telomeres from aberrant overhang accumulation. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11682-7. Hsu M, McEachern MJ, Dandjinou AT, Tzfati Y, Orr E, Blackburn EH, Lue NF. PMID: 17609387.
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Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006 Oct; 12(10):1133-8. Blackburn EH, Greider CW, Szostak JW. PMID: 17024208.
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Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11306-11. Bagheri S, Nosrati M, Li S, Fong S, Torabian S, Rangel J, Moore DH, Federman S, Laposa RR, Baehner FL, Sagebiel RW, Cleaver JE, Haqq C, Debs RJ, Blackburn EH, Kashani-Sabet M. PMID: 16847266.
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Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res. 2006 Jun 01; 66(11):5763-71. Goldkorn A, Blackburn EH. PMID: 16740715.
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Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology. 2006 Apr; 31(3):277-87. Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH. PMID: 16298085.
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Telomerase and Cancer: Kirk A. Landon–AACR prize for basic cancer research lecture. Mol Cancer Res. 2005 Sep; 3(9):477-82. Blackburn EH. PMID: 16179494.
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Cell biology: Shaggy mouse tales. Nature. 2005 Aug 18; 436(7053):922-3. Blackburn EH. PMID: 16107824.
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Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood. 2005 Aug 15; 106(4):1246-52. Ly H, Schertzer M, Jastaniah W, Davis J, Yong SL, Ouyang Q, Blackburn EH, Parslow TG, Lansdorp PM. PMID: 15886322.
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Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem. 2005 Jun 24; 280(25):23709-17. Li S, Crothers J, Haqq CM, Blackburn EH. PMID: 15831499.
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Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett. 2005 Feb 07; 579(4):859-62. Blackburn EH. PMID: 15680963.
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Thoughts of a former Council member. Perspect Biol Med. 2005; 48(2):172-80. Blackburn E. PMID: 15834190.
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Stem cell science and politics: a talk with Elizabeth Blackburn. Camb Q Healthc Ethics. 2005; 14(2):214-7. Blackburn E. PMID: 15887814.
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Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol. 2004 Dec 06; 167(5):819-30. Xu L, Blackburn EH. PMID: 15583028.
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Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol Cell Biol. 2004 Dec; 24(24):10857-67. Levy DL, Blackburn EH. PMID: 15572688.
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Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17312-5. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. PMID: 15574496.
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Processive utilization of the human telomerase template: lack of a requirement for template switching. J Biol Chem. 2004 Dec 17; 279(51):53770-81. Rivera MA, Blackburn EH. PMID: 15456773.
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A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14713-8. Lin J, Ly H, Hussain A, Abraham M, Pearl S, Tzfati Y, Parslow TG, Blackburn EH. PMID: 15371596.
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Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin Cancer Res. 2004 Aug 01; 10(15):4983-90. Nosrati M, Li S, Bagheri S, Ginzinger D, Blackburn EH, Debs RJ, Kashani-Sabet M. PMID: 15297398.
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Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res. 2004 Jul 15; 64(14):4833-40. Li S, Rosenberg JE, Donjacour AA, Botchkina IL, Hom YK, Cunha GR, Blackburn EH. PMID: 15256453.
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Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol. 2004 May; 24(9):4019-31. Makovets S, Herskowitz I, Blackburn EH. PMID: 15082794.
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Bioethics and the political distortion of biomedical science. N Engl J Med. 2004 Apr 01; 350(14):1379-80. Blackburn E. PMID: 15070784.
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A ‘full range’ of bioethical views just got narrower. Washington Post. 2004 Mar 07; B2. Blackburn EH. PMID: 15022684.View in: PubMed
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Reason as our guide. PLoS Biol. 2004 Apr; 2(4):E116. Blackburn E, Rowley J. PMID: 15024408.
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Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev. 2004 Feb 15; 18(4):387-96. Lin J, Blackburn EH. PMID: 14977919.
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Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29; 359(1441):109-21. Chan SR, Blackburn EH. PMID: 15065663.
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Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Mol Biol Cell. 2004 Apr; 15(4):1623-34. Lin J, Smith DL, Blackburn EH. PMID: 14742705.
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Tracking telomerase. Cell. 2004 Jan 23; 116(2 Suppl):S83-6, 1 p following S86. Greider CW, Blackburn EH. PMID: 15055591.
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A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA. 2003 Nov; 9(11):1323-32. Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. PMID: 14561882.
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Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol Cell Biol. 2003 Oct; 23(19):6849-56. Ly H, Blackburn EH, Parslow TG. PMID: 12972604.
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Catalytically active human telomerase mutants with allele-specific biological properties. Exp Cell Res. 2003 Aug 15; 288(2):277-87. Kim M, Xu L, Blackburn EH. PMID: 12915119.
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A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev. 2003 Jul 15; 17(14):1779-88. Tzfati Y, Knight Z, Roy J, Blackburn EH. PMID: 12832393.
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A role for a novel ‘trans-pseudoknot’ RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev. 2003 May 01; 17(9):1078-83. Ly H, Xu L, Rivera MA, Parslow TG, Blackburn EH. PMID: 12730131.
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Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell. 2003 May; 11(5):1379-87. Chan SW, Blackburn EH. PMID: 12769860.
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A molecular switch underlies a human telomerase disease. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16998-7003. Comolli LR, Smirnov I, Xu L, Blackburn EH, James TL. PMID: 12482936.
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A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev. 2002 Nov 01; 16(21):2800-12. Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR. PMID: 12414733.
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Harmful moratorium on stem cell research. Science. 2002 Sep 20; 297(5589):1957. Rowley JD, Blackburn E, Gazzaniga MS, Foster DW. PMID: 12242409.
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The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9316-21. Nautiyal S, DeRisi JL, Blackburn EH. PMID: 12084816.
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New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene. 2002 Jan 21; 21(4):553-63. Chan SW, Blackburn EH. PMID: 11850780.
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Dynamics of telomeric DNA turnover in yeast. Genetics. 2002 Jan; 160(1):63-73. McEachern MJ, Underwood DH, Blackburn EH. PMID: 11805045.
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A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity. J Biol Chem. 2002 Jan 11; 277(2):896-906. Cano MI, Blake JJ, Blackburn EH, Agabian N. PMID: 11673453.